CARDIOLOGY OF UZBEKISTAN
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publisher: I-EDU GROUP LLC
language: en
publication name: CARDIOLOGY OF UZBEKISTAN
issn: 3060-4850
items: Influence of combined pathogenetic treatment on the dynamics of epicardial fat thickness in patients with cad and metabolic syndrome
items: Universality of SPC (Single-Pill Combination) A New Approach to the Treatment of Cardiovascular Diseases: From Guidelines to Real-World Clinical Practice
items: Systematic Review of Different Reperfusion Therapy Methods in Patients with ST-Elevation Acute Coronary Syndrome: Literature Review
items: Heart remodeling in the obstructive form of hypertrophic cardiomyopathy, efficacy of Morrow septal myectomy
items: Early biomarkers of endothelial dysfunction: clinical implications for the diagnosis and management of cardiovascular disease
items: The impact of revascularizatıon vıa stenting on left ventricular ejection fraction ın patients with myocardial infarction
items: Application of the Ross operation in children with congenital aortic valve pathology
items: The Role of Adipose Tissue Depots in the Pathogenesis of Coronary Artery Disease: Beyond Body Mass Index
items: The effect of antihypertensive drugs on cognitive functions
items: Predictors of sudden cardiac death and the impact of coronary artery bypass grafting on their development
items: The importance of lipoprotein(a) in the development of cardiovascular diseases
items: Short and Medium-term Efficacy and Safety of “Sinotech+” (Uzbekistan) Stent in Primary Stenting for Patients with Acute Coronary Syndrome with ST-Segment Elevation
items: Speckle-tracking echocardiography in assessing staged cardiac remodeling in ischemic heart failure
items: Benefits and risks of implementing the Neuromed AI medical decision support system in the cardiology service of the Republic of Uzbekistan.
items: An integrated approach to determining the risk of developing preeclampsia in pregnant women with hypertensive conditions
items: Gender-specific features of dilated cardiomyopathy in the uzbek population
items: Epidemiology and Cardiovascular Risk Assessment in Patients with Carotid Artery Atherosclerosis in the Republic of Uzbekistan: A Cross-Sectional Population-Based Study
items: Comprehensive assessment of inflammatory, epigenetic, and cardioimaging biomarkers in the progressive course of coronary heart disease
items: The significance of the triglyceride/high-density lipoprotein cholesterol index as a predictor of major cardiovascular events
items: The role of high-tech noninvasive cardiovisualization methods in early diagnosis and prognosis of coronary artery disease
items: Modern Approaches to Imaging Features of Unstable Atherosclerotic Plaques in the Carotid Arteries: A Literature Review
items: Vascular complications in patients with type 2 diabetes mellitus and arterial hypertension: risk factors and prevention
items: Comparison of the effectiveness of the original and generic forms of clopidogrel in patients with coronary artery disease (CAD).4o
items: Polypill in Cardiovascular Disease Prevention: Efficacy and Perspectives
items: Systematic Review of Valve Surgery with Continuous Coronary Perfusion on Beating Heart in Patients with Low Left Ventricular Ejection Fraction.
items: Cardiological approaches to the diagnosis and treatment of patients with combined atherosclerotic stenosis of the carotid and coronary arteries
items: Clınıcal and laboratory dıfferences between stentıng and optımal medıcal therapy ın the treatment of coronary artery dısease.
items: Surgical treatment of post-infarction ventricular septal defect and left ventricular aneurysm
items: Clinical case of pseudo-Wellens syndrome caused by pulmonary embolism
items: Correlation analysis of the interdependence between identified risk factors of ischemic heart disease and vitamin d levels

Influence of combined pathogenetic treatment on the dynamics of epicardial fat thickness in patients with cad and metabolic syndrome
type: item
description: Aim. To evaluate the influence of combined hypolipidemic therapy (statins in combination with ezetimibe and fenofibrate) and sodium-glucose cotransporter 2 inhibitors on epicardial fat thickness in patients with coronary heart disease and metabolic syndrome. Materials and methods: The study included 49 patients with coronary heart disease and metabolic syndrome who underwent treatment at the Republican Specialized Scientific and Practical Medical Center of Cardiology. The patients were divided into 2 groups: 1) intensive statin therapy in combination with ezetimibe, 2) with the addition of fenofibrate and SGLT2 inhibitors. All patients underwent biochemical tests and imaging marker assessments, followed by comparison of the dynamics within and between groups. Results. When comparing two groups receiving different types of therapy, both groups demonstrated a significant decrease in lipid parameters: LDL-C p<0.001, TC p<0.001, TG p<0.001. Additionally, the group treated with fenofibrate and SGLT2 inhibitors showed a more significant reduction in epicardial fat (11.4 mm in the first group and 10.4 mm in the second group, p<0.05). Conclusion: Pathogenetic therapy with the inclusion of fenofibrate and SGLT2 inhibitors more effectively reduces the level of EFT, as well as TG, VLDL-C, and the TG/HDL index.
subject: Article
  topic: section
subject: coronary artery disease
  topic: keywords
subject: epicardial fat thickness
  topic: keywords
subject: sodium glucose co-transporter 2 inhibitors
  topic: keywords
subject: metabolic syndrome
  topic: keywords
subject: fenofibrate
  topic: keywords
creator: Andrey Kim
creator: Aleksandr Shek
creator: Rano Alieva
rights: Copyright (c) 2025 А.Р. Ким , А.Б. Шек , Р.Б. Алиева (Автор) https://creativecommons.org/licenses/by/4.0
date: 2025-09-30
publication date: 2025-09-30
starting page: 199
ending page: 208
doi: 10.70626/cardiouz-2025-2-52

Universality of SPC (Single-Pill Combination) A New Approach to the Treatment of Cardiovascular Diseases: From Guidelines to Real-World Clinical Practice
type: item
description: In the modern ESH (2023) and ESC (2024) guidelines on arterial hypertension (AH), the following key provisions for the use of combination therapies from the start of treatment have been clearly formulated for the first time: the use of single-pill combinations (SPCs) should be preferred at any stage of treatment, i.e., at the initiation of therapy with a combination of two drugs and at any other stage of treatment (Class I recommendation, Level of Evidence B). These statements have also been incorporated into the 2024 clinical guidelines on AH in adults by the Russian Cardiological Society (RCS) and the 2025 National Clinical Protocol on AH by the Ministry of Health of the Republic of Uzbekistan. This article presents a new approach to the treatment of cardiovascular diseases using universal SPCs in real-world clinical practice
subject: Clinical case
  topic: section
subject: cardiovascular diseases
  topic: keywords
subject: arterial hypertension
  topic: keywords
subject: ischemic heart disease
  topic: keywords
subject: chronic heart failure
  topic: keywords
subject: single pill combination
  topic: keywords
subject: fixed-dose combination
  topic: keywords
creator: Khurshid Fozilov
creator: Gulnoz Khamidullaeva
creator: Guzal Abdullaeva
creator: Guzal Mullabaeva
creator: Nazima Salimova
creator: Krzysztof Filipiak
rights: Copyright (c) 2025 Х.Г. Фозилов , Г.А. Хамидуллаева , Г.Дж. Абдуллаева , Г.У. Муллабаева , Н.Р. Салимова , К.Ю. Филипяк (Автор) https://creativecommons.org/licenses/by/4.0
date: 2025-09-30
publication date: 2025-09-30
starting page: 217
ending page: 234
doi: 10.70626/cardiouz-2025-2-54

Systematic Review of Different Reperfusion Therapy Methods in Patients with ST-Elevation Acute Coronary Syndrome: Literature Review
type: item
description: Aim. Systematic analysis and comparison of different reperfusion therapy methods in patients with ST-elevation acute coronary syndrome (STEMI), including primary percutaneous coronary intervention (pPCI) and thrombolytic therapy (TLT), with emphasis on time factor and COVID-19 pandemic impact. Materials and methods. A systematic review of prospective randomized and observational studies comparing pPCI and TLT effectiveness in STEMI patients was conducted. Data from major international trials including DANAMI-2 (1572 patients), PRAGUE-2, STAT, GISSI, ISACS-STEMI COVID-19, meta-analyses of 23 studies, and modern global longitudinal strain assessment methods were analyzed. Results. Meta-analysis of 23 randomized studies showed statistically significant pPCI advantages over TLT: 30-day mortality 8.0% vs 13.7% (p=0.0003), recurrent infarction 3.8% vs 7.0% (p<0.05), revascularization need 5.7% vs 25.2% (p<0.001). "Golden hour" concept was confirmed. COVID-19 pandemic led to 19-30.5% reduction in STEMI presentations and worse prognosis. Conclusion. pPCI demonstrates statistically significant advantages over TLT, however method selection should consider time factor and technical availability. Modern global longitudinal strain assessment methods improve prognostic accuracy.
subject: Article / Review
  topic: section
subject: acute coronary syndrome
  topic: keywords
subject: reperfusion therapy
  topic: keywords
subject: primary PCI
  topic: keywords
subject: thrombolysis
  topic: keywords
subject: global longitudinal strain
  topic: keywords
subject: COVID-19
  topic: keywords
creator: Khurshid Fozilov
creator: Bakhtiyor Atamuratov
rights: Copyright (c) 2025 Х.Г. Фозилов, Б.Р. Атамуратов (Автор) https://creativecommons.org/licenses/by/4.0
date: 2025-09-30
publication date: 2025-09-30
starting page: 277
ending page: 283
doi: 10.70626/cardiouz-2025-2-59

Heart remodeling in the obstructive form of hypertrophic cardiomyopathy, efficacy of Morrow septal myectomy
type: item
description: Obstructive hypertrophic cardiomyopathy (OHCMP) is a disease characterized by cardiac remodeling due to genetic factors. OHCMP can cause the development of dynamic obstruction in the outflow tract of the left ventricle, diastolic dysfunction, mitral regurgitation, myocardial ischemia, and cardiac arrhythmias. Clinically, patients are manifested by symptoms of heart failure. OHCMP is the most common cause of sudden cardiac death, especially in young people and among athletes. According to the results of epidemiological observations conducted in the USA and European countries, sudden cardiac death in athletes under 35 years of age is associated with OHCMP in 30–40% of cases. Today, despite the availability of modern non-invasive methods of treating the disease, the effectiveness of the surgical method prevails. The article analyzes the data presented in the literature on the features of cardiac remodeling in this disease, the results of clinical studies conducted in this area, and the effectiveness of treatment methods
subject: Article / Review
  topic: section
subject: hypertrophic cardiomyopathy
  topic: keywords
subject: Morrow myectomy
  topic: keywords
subject: astolic dysfunction
  topic: keywords
subject: cardiac remodeling
  topic: keywords
creator: Nargis Rasulova
creator: Timur Abdullayev
creator: Adhamjon Hakimov
rights: Copyright (c) 2025 Н. Расулова, Т.А. Абдуллаев, А.А. Хакимов (Автор) https://creativecommons.org/licenses/by/4.0
date: 2025-09-30
publication date: 2025-09-30
starting page: 270
ending page: 276
doi: 10.70626/cardiouz-2025-2-58

Early biomarkers of endothelial dysfunction: clinical implications for the diagnosis and management of cardiovascular disease
type: item
description: This review synthesizes current evidence on early biomarkers of endothelial dysfunction (ED) in cardiovascular disease (CVD), emphasizing their role in diagnosis, prognosis, and management. ED, characterized by reduced nitric oxide bioavailability and increased inflammation, serves as a reversible precursor to atherosclerosis, thrombosis, and events like myocardial infarction. Established biomarkers, including adhesion molecules, cytokines, and inflammatory markers, reflect endothelial activation and predict CVD risk, with recent studies confirming their utility in hypertension. Emerging focus on L-arginine derivatives, particularly asymmetric dimethylarginine (ADMA), highlights its specificity as an endogenous nitric oxide synthase inhibitor, associated with vascular impairment in hypertension, diabetes, and CVD. Clinical trials, such as the AtheroGene and Framingham Offspring studies, demonstrate ADMA’s prognostic value for major adverse events. Future directions advocate integrating ADMA into multi-biomarker panels with AI and omics for personalized medicine, addressing gaps in standardization and early detection. Non-invasive techniques like flow-mediated dilation and ultrasound-derived markers complement biomarkers for subclinical CVD assessment. Overall, biomarker-driven strategies promise enhanced CVD prevention and tailored therapies.
subject: Article / Review
  topic: section
subject: endothelial dysfunction
  topic: keywords
subject: asymmetric dimethylarginine
  topic: keywords
subject: homeostasis
  topic: keywords
subject: nitric oxide
  topic: keywords
subject: biomarker
  topic: keywords
creator: Nargiza Nurillayeva
creator: Nigora Srojidinova
creator: Munisakhon Makhkamova
creator: Lola Khafizova
rights: Copyright (c) 2025 Н.М. Нуриллаева, Н.З. Срожидинова, М.А. Махкамова, Л. Хафизова (Автор) https://creativecommons.org/licenses/by/4.0
date: 2025-09-30
publication date: 2025-09-30
starting page: 261
ending page: 269
doi: 10.70626/cardiouz-2025-2-57

The impact of revascularizatıon vıa stenting on left ventricular ejection fraction ın patients with myocardial infarction
type: item
description: Aim. To evaluate the one-year dynamic effect of complete or incomplete revascularization on left ventricular ejection fraction (LVEF) in patients with a history of myocardial infarction (MI) who have preserved or mildly reduced LVEF. Materials and methods. The study included 270 patients with a history of MI. All patients underwent transthoracic echocardiography and coronary angiography (CAG) based on clinical examination findings. Depending on the number of affected atherosclerotic coronary vessels and the extent of stenting performed, patients were divided into three groups: Complete revascularization (CR) (n=115), Incomplete revascularization (IR) (n=94), and No revascularization (NR) (n=61). After the procedure, all patients were discharged with standard treatment. After one year, follow-up echocardiographic assessment of LVEF was performed. Results. In the CR group, LVEF increased significantly from 54.0 [47.0; 59.7] to 55.7 [46.9; 61.4] (p = 0.017). In the IR group, LVEF increased from 53.9 [43.7; 56.4] to 55.7 [46.9; 61.4], but the change was not statistically significant (p = 0.458). In the NR group, LVEF decreased from 50.7 [45.0; 56.3] to 48.2 [41.8; 54.3] (p = 0.011). No statistically significant differences were observed between groups in terms of diastolic function parameters of the left ventricle. Conclusion. In post-infarction patients, complete anatomical revascularization of affected coronary arteries via stenting has a significantly positive impact on the improvement of LVEF.
subject: Article
  topic: section
subject: myocardial infarction
  topic: keywords
subject: ejection fraction
  topic: keywords
subject: stenting
  topic: keywords
subject: revascularization
  topic: keywords
subject: heart failure
  topic: keywords
creator: Ergashali Tursunov
creator: Ravshanbek Kurbanov
creator: Nodir Zakirov
rights: Copyright (c) 2025 Э.Я. Турсунов, Р.Д. Курбанов, Н.У. Закиров (Автор) https://creativecommons.org/licenses/by/4.0
date: 2025-09-30
publication date: 2025-09-30
starting page: 189
ending page: 198
doi: 10.70626/cardiouz-2025-2-51

Application of the Ross operation in children with congenital aortic valve pathology
type: item
description: Aim. To evaluate the clinical effectiveness and safety of the Ross procedure in children with congenital aortic valve disease. The main aim of the study was to determine the physiological and hemodynamic advantages of the Ross operation compared to conventional valve replacement techniques. Materials and methods. A total of 14 pediatric patients who underwent the Ross procedure at the Medion Innovation Center between 2022 and 2025 were analyzed. The primary diagnoses were aortic stenosis (n = 9) and aortic insufficiency (n = 5). In all cases, the full-root replacement technique was applied. Postoperative echocardiographic parameters, including transvalvular pressure gradient and degree of regurgitation, were assessed. Results. A significant improvement in postoperative hemodynamic parameters was observed in all patients. The mean aortic pressure gradient decreased from 45 ± 12 mm Hg to 8 ± 3 mm Hg, and no clinically significant regurgitation was detected. No early postoperative complications or autograft dysfunction were reported during the follow-up period. Conclusion. The Ross procedure is an effective and safe surgical method for treating congenital aortic valve pathology in children. It restores near-physiological hemodynamics, improves long-term outcomes, and reduces the need for reoperation. The results support broader implementation of the Ross procedure in pediatric cardiac surgery practice.
subject: Article
  topic: section
subject: Ross procedure
  topic: keywords
subject: congenital aortic stenosis
  topic: keywords
subject: aortic insufficiency
  topic: keywords
subject: pediatric cardiac surgery
  topic: keywords
subject: aortic root replacement
  topic: keywords
subject: echocardiography
  topic: keywords
subject: hemodynamics
  topic: keywords
creator: Yuri Sinelnikov
creator: Arabbek Kayumov
creator: Shohruh Adylov
creator: Nigora Zakirova
creator: Egor Lyzhin
rights: Copyright (c) 2025 Ю.С. Синельников, А.Р. Каюмов, Ш.Ш. Адилов, Н.А. Зоирова, Е.М. Лыжин (Автор) https://creativecommons.org/licenses/by/4.0
date: 2025-10-17
publication date: 2025-10-17
starting page: 180
ending page: 188
doi: 10.70626/cardiouz-2025-2-50

The Role of Adipose Tissue Depots in the Pathogenesis of Coronary Artery Disease: Beyond Body Mass Index
type: item
description: In recent years, researchers have focused on the role of various adipose tissue depots in the development of coronary artery disease (CAD), extending beyond traditional obesity assessments based on body mass index (BMI). Visceral adipose tissue, epicardial fat, fatty liver disease (currently termed metabolic dysfunction-associated steatotic liver disease), and perivascular adipose tissue actively participate in CAD pathogenesis through mechanisms of systemic inflammation, oxidative stress, endothelial dysfunction, and atherosclerosis. Visceral fat, characterized by high metabolic activity, secretes proinflammatory cytokines that promote insulin resistance and atherosclerosis. Epicardial fat surrounding the coronary arteries exerts local effects by releasing adipokines that may accelerate the progression of atherosclerotic plaques. Fatty liver disease is associated with dyslipidemia and enhanced systemic inflammation, increasing cardiovascular risk. Perivascular adipose tissue regulates vascular tone and inflammation, and its dysfunction contributes to arterial stiffness and hypertension. The relevance of studying these adipose depots lies in the need to identify new biomarkers and targets for personalized prevention and treatment of CAD. Traditional obesity assessment methods such as BMI, fail to reflect adipose tissue distribution and metabolic activity, underscoring the importance of more detailed investigation into the role of various fat depots in cardiovascular pathology.
subject: Article / Review
  topic: section
subject: coronary artery disease
  topic: keywords
subject: local adipose depots
  topic: keywords
subject: obesity
  topic: keywords
subject: visceral obesity
  topic: keywords
subject: epicardial adipose tissue
  topic: keywords
subject: metabolic dysfunction-associated steatotic liver disease
  topic: keywords
subject: perivascular adipose tissue
  topic: keywords
creator: Dilnora Yusupaliyeva
creator: Rano Aliyeva
creator: Shokhista Akhmedova
creator: Aleksandr Shek
rights: Copyright (c) 2025 Д.Б. Юсупалиева , Р.Б. Алиева , Ш.С. Ахмедова , А.Б. Шек (Автор) https://creativecommons.org/licenses/by/4.0
date: 2025-09-30
publication date: 2025-09-30
starting page: 245
ending page: 260
doi: 10.70626/cardiouz-2025-2-56

The effect of antihypertensive drugs on cognitive functions
type: item
description: According to the World Health Organization data, 1.13 billion people worldwide suffer from arterial hypertension, with only 21% under proper control. Dementia currently negatively affects the quality of life of 55 million people worldwide, with one new case recorded every 3.2 seconds. Analyzing the effects of antihypertensive medications on cognitive function and evaluating protective mechanisms against dementia development is currently considered one of the urgent issues. There is reliable evidence that the effects of antihypertensive medications on cognitive function are related not only to blood pressure reduction but also to independent neuroprotective mechanisms. Angiotensin receptor blockers reduce dementia risk by 12-26% compared to other antihypertensive medications. Calcium channel blockers demonstrate 17% greater neuroprotective effects compared to other drug classes. ARBs and calcium channel blockers possess the best neuroprotective properties and are considered preferable for cognitive function protection. These effects occur independently of blood pressure reduction mechanisms.
subject: Article / Review
  topic: section
subject: sudden cardiac death
  topic: keywords
subject: ischemic heart disease
  topic: keywords
subject: ventricular arrhythmias
  topic: keywords
subject: left ventricular ejection fraction
  topic: keywords
subject: myocardial scar tissue
  topic: keywords
subject: coronary artery bypass grafting
  topic: keywords
subject: risk stratification
  topic: keywords
subject: secondary prevention
  topic: keywords
subject: cardiovascular mortality
  topic: keywords
creator: Munisa Atoeva
creator: Guzal Abdullaeva
creator: Khafiza Yusupova
creator: Iroda Ibragimova
rights: Copyright (c) 2025 М.И. Атоева, Г.Ж. Абдуллаева, Х.Ф. Юсупова, И.В. Ибрагимова (Автор) https://creativecommons.org/licenses/by/4.0
date: 2025-06-30
publication date: 2025-06-30
starting page: 167
ending page: 176
doi: 10.70626/cardiouz-2025-2-00049

Predictors of sudden cardiac death and the impact of coronary artery bypass grafting on their development
type: item
description: Sudden Cardiac Death (SCD) is one of the most severe and life-threatening manifestations of cardiovascular diseases and is among the leading causes of mortality worldwide. The primary pathogenic factors contributing to the development of this condition include ischemic heart disease (IHD), ventricular arrhythmias, reduced left ventricular ejection fraction (LVEF), and the formation of scar tissue in the myocardium. The mechanism underlying SCD is complex, involving a combination of myocardial ischemia, electrical instability, and morphological changes, all of which contribute to the onset of malignant arrhythmias. Coronary artery bypass grafting (CABG) is an effective revascularization technique in patients with ischemic heart disease. It not only alleviates symptoms but also significantly improves long-term prognosis by enhancing cardiac function. Studies have shown that CABG, particularly in patients with reduced LVEF, decreases overall mortality and the risk of developing SCD. In conclusion, CABG plays an important role in the prevention of SCD, but it is not a standalone solution. A thorough analysis of the underlying risk factors, early identification of high-risk patients, and the development of individualized, comprehensive preventive and therapeutic strategies represent the most effective approach in reducing SCD incidence.
subject: Article / Review
  topic: section
subject: sudden cardiac death
  topic: keywords
subject: ischemic heart disease
  topic: keywords
subject: ventricular arrhythmias
  topic: keywords
subject: left ventricular ejection fraction
  topic: keywords
subject: myocardial scar tissue
  topic: keywords
subject: coronary artery bypass grafting
  topic: keywords
subject: risk stratification
  topic: keywords
subject: secondary prevention
  topic: keywords
subject: cardiovascular mortality
  topic: keywords
creator: Alisher Rasulov
creator: Ravshanbek Kurbanov
creator: Guzal Mullabaeva
creator: Ergashali Tursunov
creator: Amayak Kevorkov
creator: Qadriddin Sayfiddin Hoji
rights: Copyright (c) 2025 А.Ш. Расулов, Р.Д. Курбанов, Г.У. Муллабаева, Э.Я. Турсунов, А.Г. Кеворков, К.Ш. Сайфиддин Ходжи (Автор) https://creativecommons.org/licenses/by/4.0
date: 2025-06-30
publication date: 2025-06-30
starting page: 157
ending page: 166
doi: 10.70626/cardiouz-2025-2-00048

The importance of lipoprotein(a) in the development of cardiovascular diseases
type: item
description: Aim. To study the impact of lipoprotein (a) levels on major cardiovascular events. Materials and methods. We examined the impact of lipoprotein(a) levels on major cardiovascular events based on a review of articles on this topic. Results. Based on a review of articles on this topic, it can be said that Lp(a) is a highly atherothrombogenic lipoprotein associated with atherosclerotic cardiovascular diseases and their complications, in particular, ischemic heart disease and aortic valve stenosis. Conclusion. Lipoprotein (a) levels may serve as a criterion for determining residual risk during hypolipidemic therapy.
subject: Article / Review
  topic: section
subject: lipoprotein(a)
  topic: keywords
subject: cardiovascular risk
  topic: keywords
subject: cardiovascular complications
  topic: keywords
subject: aortic stenosis
  topic: keywords
creator: Raushan Jemuratova
creator: Aleksandr Shek
rights: Copyright (c) 2025 Р.Е. Жемуратова , А.Б. Шек (Автор) https://creativecommons.org/licenses/by/4.0
date: 2025-06-30
publication date: 2025-06-30
starting page: 150
ending page: 156
doi: 10.70626/cardiouz-2025-2-00047

Short and Medium-term Efficacy and Safety of “Sinotech+” (Uzbekistan) Stent in Primary Stenting for Patients with Acute Coronary Syndrome with ST-Segment Elevation
type: item
description: Aim. To evaluate the efficacy and safety of the Uzbekistan-manufactured “Sinotech+” stent during primary percutaneous coronary intervention (pPCI) in patients presenting with ST-elevation acute coronary syndrome (STEMI). Materials and methods. The study was conducted at the X-ray Endovascular Treatment Department of Cardiovascular Diseases at the RSSPMCC. Between January and June 2025, all 31 patients diagnosed with STEMI underwent pPCI procedures. "Sinotech+" stents were implanted in 17 patients (54.8%), while "Resolute Integrity" stents were implanted in 14 patients (45.2%). Patients who received "Sinotech+" stent implantation were analyzed. Results. Coronary lesion distribution was as follows: single-vessel disease in 5 patients (29.4%), two- vessel disease in 7 patients (41.2%), and multi-vessel disease in 5 patients (29.4%). Pre-procedural coronary flow assessment using the TIMI (Thrombolysis in Myocardial Infarction) perfusion scale revealed TIMI-0 flow in 9 patients (53%) and TIMI-1 flow in 8 patients (47%). Following pPCI, TIMI-3 flow was achieved in 14 patients (82.4%), while TIMI-2 flow was achieved in the remaining 3 patients (17.6%). These results demonstrated 100% technical success (stent deployment and vessel opening) and 82.4% angiographic success (achieving TIMI-3 flow), indicating high clinical efficacy of primary PCI using “Sinotech+” stents. Conclusion. The Uzbekistan-manufactured “Sinotech+” stent demonstrated high efficacy and safety in patients presenting with STEMI. No complications (thrombosis, restenosis, recurrent myocardial infarction, repeat revascularization) were observed during clinical follow-up.
subject: Article
  topic: section
subject: STEMI
  topic: keywords
subject: pPCI
  topic: keywords
subject: “Sinotech+”
  topic: keywords
subject: TIMI
  topic: keywords
creator: Khurshid Fozilov
creator: Bakhtiyor Atamuratov
creator: Bakhtiyor Yuldashov
rights: Copyright (c) 2025 Х .Фозилов, Б. Атамуратов, Б. Юлдашов (Автор) https://creativecommons.org/licenses/by/4.0
date: 2025-06-30
publication date: 2025-06-30
starting page: 108
ending page: 119
doi: 10.70626/cardiouz-2025-2-00043

Speckle-tracking echocardiography in assessing staged cardiac remodeling in ischemic heart failure
type: item
description: Aim. To assess the features of global staged remodeling of the heart chambers in patients with ischemic chronic heart failure, depending on the degree of left ventricular ejection fraction (LVEF) reduction, using two-dimensional echocardiography with myocardial deformation analysis. Materials and methods. The study included 96 patients with a confirmed diagnosis of CHF according to current criteria. Patients were divided into three groups based on LVEF: Group I – LVEF >50% (n=46, preserved systolic function); Group II – LVEF 40-49% (n=24, mildly reduced systolic function); Group III – LVEF <40% (n=26, significantly reduced systolic function). Global longitudinal strain (GLS) of the LV was significantly lower in patients with reduced ejection fraction. Results. In the group with LVEF >50%, the mean GLS was 17.0 ± 2.8%, while in those with LVEF 40–49% and <40%, values decreased to 12.6 ± 2.1% and 9.4 ± 2.2%, respectively (p < 0.001). A similar trend was observed for GLS measured in 4-, 2-, and 3-chamber views. These findings indicate high sensitivity of GLS to impaired myocardial contractility and confirm its clinical significance in assessing LV functional status.The assessment of LA function using 2D speckle-tracking echocardiography in the reservoir, conduit, and contractile phases also revealed a significant decrease in absolute parameters: LASr (reservoir phase) - 35.5 ± 8.3% (LVEF >50%) →17.8 ± 11.2% (LVEF <40%), *p* < 0.001; LASct (conduit phase) - 17.6 ± 5.4% → 8.8 ± 6.5%, *p*< 0.001; LAScd (contractile phase) - 18.7 ± 5.9% → 8.7 ± 4.6%, *p* < 0.001. In patients with LVEF>50%, RV longitudinal strain parameters were highest (RVFWLS - 21.3 ± 4.0%; RV GLS - 18.1 ± 3.2%), while in LVEF 40–49%, they decreased (19.9 ± 2.8% and 16.0 ± 2.7%, respectively), and in LVEF <40%, the most pronounced decline was observed (RVFWLS: 14.0 ± 4.1%; RV GLS: 10.5 ± 3.1%), with significant intergroup differences (p=0.001). Conclusion. Patients with ischemic CHF exhibit progressive re…
subject: Article
  topic: section
subject: Speckle tracking
  topic: keywords
subject: Global Longitudinal Strain
  topic: keywords
subject: Chronic Heart Failure
  topic: keywords
creator: Feruza Bekmetova
creator: Khurshid Fozilov
creator: Regina Bekbulatova
creator: Shavkat Khoshimov
creator: Sherzod Orinbaev
rights: Copyright (c) 2025 Ф.М. Бекметова , Х.Г. Фозилов , Р.Ш. Бекбулатова , Ш.У. Хошимов , Ш.А. Оринбаев (Автор) https://creativecommons.org/licenses/by/4.0
date: 2025-06-30
publication date: 2025-06-30
starting page: 120
ending page: 130
doi: 10.70626/cardiouz-2025-2-00044

Benefits and risks of implementing the Neuromed AI medical decision support system in the cardiology service of the Republic of Uzbekistan.
type: item
description: Aim: Clinical testing of the NeuromedAI Cardio intelligent system, designed to automate routine tasks of cardiologists and improve the quality of medical care; Materials and methods. The study used the NeuromedAI Cardio intelligent system and a questionnaire, including 28 questions aimed at expert assessment of the potential benefits of the system for doctors. The questionnaire helped to define the main requirements for the system, as well as formulate recommendations for improving the model. In particular, areas were identified for enriching the training dataset and further training the model in order to improve the accuracy of responses; Results. As part of a pilot study of the Neuromed system conducted in 2024, an anonymous survey of 21 cardiologists was organized. The average experience of the participants was 17 ± 11.1 years. Analysis of the questionnaires showed that during interaction with the system, specialists asked a total of 400 questions, which reflects a high level of interest in the technology and its active testing in the professional environment; Conclusion. Based on the obtained results, it is planned to develop recommendations for adapting the system for implementation in the practice of primary health care in the Republic of Uzbekistan. It is expected that the adapted system will improve the accuracy of diagnosis and the effectiveness of treatment at the primary level, which will be reflected in the improvement of key indicators of public health and will receive positive feedback from health workers.
subject: Article
  topic: section
subject: intelligent system
  topic: keywords
subject: cardiologist
  topic: keywords
subject: risk assessment
  topic: keywords
subject: unstructured data
  topic: keywords
subject: clinical decision support
  topic: keywords
creator: Khurshid Fozilov
creator: Raisa Trigulova
rights: Copyright (c) 2025 Х.Г. Фозилов, Р.Х. Тригулова (Автор) https://creativecommons.org/licenses/by/4.0
date: 2025-03-30
publication date: 2025-03-30
starting page: 46
ending page: 57
doi: 10.70626/cardiouz-2025-2-00037

An integrated approach to determining the risk of developing preeclampsia in pregnant women with hypertensive conditions
type: item
description: Aim. Hypertensive disorders complicate one in ten pregnancies, which necessitates the development of new standards for determining the risk of preeclampsia and heart failure in pregnant women. To determine early clinical markers in pregnant women with gestational arterial hypertension (GAH) as sensitive diagnostic criteria for the development of hypertensive complications. Materials and methods. The study included 91 pregnant women of the 2nd-3rd trimesters, divided into groups: healthy pregnant women (n=44) and with GAH (n=47) according to the ESC Guidelines 2018. Physical examination, blood pressure measurement, BMI calculation, detailed blood tests including lipidogram, coagulogram, determination of prolactin and NT-proBNP, echocardiography, vascular stress test to assess endothelial function were performed. Results. Pregnant women with GAH were found to have morphofunctional changes in the heart, early signs of endothelial dysfunction, lipid and carbohydrate metabolism disorders. Microalbuminuria demonstrated high diagnostic value for detecting early renal dysfunction. The prognostic significance of prolactin and NT-proBNP levels was established. Conclusion. Comprehensive early monitoring of clinical and biochemical parameters of pregnant women with GAG is necessary for timely detection of preeclampsia predictors. The results contribute to the improvement of diagnostic and preventive standards for the management of this cohort of patients.
subject: Article
  topic: section
subject: arterial hypertension
  topic: keywords
subject: preeclampsia
  topic: keywords
subject: heart failure
  topic: keywords
subject: maternal mortality
  topic: keywords
subject: endothelial dysfunction
  topic: keywords
subject: left ventricular hypertrophy
  topic: keywords
subject: overweight
  topic: keywords
subject: microalbuminuria
  topic: keywords
subject: prolactin
  topic: keywords
subject: brain natriuretic peptide
  topic: keywords
creator: Mokhinur Sadulloeva
creator: Feruza Zakirova
creator: Malika Tursunova
creator: Abror Abdukhakimov
creator: Saida Ikramova
creator: Vasilakhon Djuraeva
rights: Copyright (c) 2025 M. Садуллоева, Ф.А. Закирова , М.У. Турсунова , А.А. Абдухакимов , С.А. Икрамова , В.Х. Джураева (Автор) https://creativecommons.org/licenses/by/4.0
date: 2025-06-30
publication date: 2025-06-30
starting page: 97
ending page: 107
doi: 10.70626/cardiouz-2025-2-00042

Gender-specific features of dilated cardiomyopathy in the uzbek population
type: item
description: Dilated cardiomyopathy (DCM) is one of the most common non-ischemic myocardial disease characterized by systolic dysfunction and cardiac chamber dilation. Gender-specific features of DCM progression and prognosis remain understudied. Aim. To evaluate gender-specific characteristics of medical history, clinical presentation, and functional parameters in patients with DCM in the Uzbek population. Materials and methods. A retrospective analysis included 269 DCM patients (180 men, 89 women) treated at the Republican Specialized Scientific-Practical Medical Center of Cardiology from 2010 to 2017. Data on age at diagnosis, disease duration, hospitalizations, NYHA class, hemodynamics, and six-minute walking test were assessed. Statistical analysis involved t-test and χ2 test (p < 0.05). Results. Women were younger at diagnosis (33.7 vs. 41.3 years; p < 0.001), had shorter disease duration (p = 0.041), and were hospitalized more frequently (75% vs. 65%; p = 0.041). No significant differences were found in NYHA class, blood pressure, or respiratory parameters. Men demonstrated better physical endurance (p = 0.191). Conclusion. Significant gender differences were identified, underscoring the need for personalized management of DCM patients.
subject: Article
  topic: section
subject: dilated cardiomyopathy
  topic: keywords
subject: gender differences
  topic: keywords
subject: retrospective analysis
  topic: keywords
subject: Uzbek population
  topic: keywords
creator: Timur Abdullayev
creator: Igor Soy
creator: Khumoyun Gulomov
creator: Saodat Mirzarakhimova
creator: Otabek Khudoyberganov
creator: Makhmud Rakhmatov
rights: Copyright (c) 2025 Т.A. Абдуллаев , И.А. Цой , Х.А. Гуломов , С.Т. Мирзарахимова , О.К. Худойберганов , М.М. Рахматов (Автор) https://creativecommons.org/licenses/by/4.0
date: 2025-03-30
publication date: 2025-03-30
starting page: 39
ending page: 45
doi: 10.70626/cardiouz-2025-2-00036

Epidemiology and Cardiovascular Risk Assessment in Patients with Carotid Artery Atherosclerosis in the Republic of Uzbekistan: A Cross-Sectional Population-Based Study
type: item
description: Aim. Atherosclerosis of the carotid artery basin is a key pathogenic factor in ischemic stroke. In the context of a lack of local epidemiological data, studying the prevalence of lesions and associated risk factors in the Republic of Uzbekistan is of particular importance. The aim of the study was to assess the prevalence of atherosclerotic lesions in the carotid arteries, identify associated risk factors, and perform cardiovascular risk stratification using the SCORE scale among the adult population of Uzbekistan, taking into account gender, age, and regional characteristics. Materials and Methods. A population-based cross-sectional study was conducted at the Republican Specialized Scientific and Practical Medical Center of Cardiology (Tashkent). The analysis included data from 6,425 adult patients who underwent ultrasound duplex scanning of the carotid arteries. Demographic indicators, blood pressure levels, lipid profile, smoking status, presence of arterial hypertension (AH), and 10-year cardiovascular risk according to the SCORE scale were assessed. For statistical analysis, univariate and multivariate logistic regression models were used. Results. Atherosclerotic lesions of the carotid arteries were significantly more frequently detected in men over 50 years of age (p<0.05). The strongest correlation was found with arterial hypertension (r=0.85; p<0.001). Smoking and elevated systolic blood pressure showed a moderate association with plaque presence (p<0.01). Mean SCORE values in certain regions (Samarkand and Navoi regions) reached Conclusion. These findings emphasize the need to implement targeted preventive programs aimed at controlling hypertension and reducing smoking prevalence in high-risk groups.
subject: Article
  topic: section
subject: carotid artery atherosclerosis
  topic: keywords
subject: cardiovascular risk
  topic: keywords
subject: SCORE scale
  topic: keywords
subject: arterial hypertension
  topic: keywords
creator: Feruza Bekmetova
creator: Khurshid Fozilov
creator: Saodat Abdullaeva
creator: Munojay Khotamova
creator: A Almonova
creator: Shukhratjon Doniyorov
rights: Copyright (c) 2025 Ф.М. Бекметова , Х.Г. Фозилов , С.Я. Абдуллаева , М.Н. Хотамова , А.Ш. Алманова , Ш.Н. Дониёров (Автор) https://creativecommons.org/licenses/by/4.0
date: 2025-09-30
publication date: 2025-09-30
starting page: 209
ending page: 216
doi: 10.70626/cardiouz-2025-2-53

Comprehensive assessment of inflammatory, epigenetic, and cardioimaging biomarkers in the progressive course of coronary heart disease
type: item
description: Aim. In this study, the prognostic significance of a multibiomarker model, including epigenetic markers (miR-155), inflammatory cytokines (TNF-α, IL-1β) and noninvasive cardiovisualizing patterns, was evaluated for assessing the risk of progressive coronary heart disease (CHD). Materials and methods. A comprehensive assessment of correlations between the parameters of coronary atherosclerosis according to contrast MSCT angiography (coronary calcium index, degree of stenosis, remodeling index, index of involvement-SIS, density, volume and mass of plaques) and biomarker levels was carried out in 152 patients with stable and unstable forms of coronary artery disease. miR-155 expression was determined by real-time polymerase chain reaction on a Rotor–Gene Q device, and concentrations of proinflammatory cytokines were determined by enzyme immunoassay. Results. A comprehensive assessment of correlations between the parameters of coronary atherosclerosis according to contrast MSCT angiography (coronary calcium index, degree of stenosis, remodeling index, index of involvement-SIS, density, volume and mass of plaques) and biomarker levels was carried out in 152 patients with stable and unstable forms of coronary artery disease. miR-155 expression was determined by real-time polymerase chain reaction on a Rotor–Gene Q device, and concentrations of proinflammatory cytokines were determined by enzyme immunoassay. Conclusion. The data obtained confirm that this multibiomarker panel is a promising tool for early detection, risk assessment, and the development of individual management strategies for patients with coronary heart disease. Combined assessment of epigenetic, inflammatory, and cardiovisual biomarkers can improve risk stratification and aid in clinical decision-making.
subject: Article
  topic: section
subject: Cardiovascular diseases
  topic: keywords
subject: coronary heart disease
  topic: keywords
subject: epigenetic markers
  topic: keywords
subject: microRNA 155
  topic: keywords
subject: inflammatory cytokines
  topic: keywords
subject: TNF-α, IL-1b
  topic: keywords
subject: imaging biomarkers
  topic: keywords
subject: MSCT- angiography of coronary vessels
  topic: keywords
subject: diagnosis
  topic: keywords
subject: prognosis
  topic: keywords
creator: Feruza Abdumalikova
creator: Nargiza Nurillaeva
creator: Bernara Kurbanova
rights: Copyright (c) 2025 Ф.Б. Абдумаликова , Н.М. Нуриллаева , Б.Г. Курбанова (Автор) https://creativecommons.org/licenses/by/4.0
date: 2025-06-30
publication date: 2025-06-30
starting page: 131
ending page: 142
doi: 10.70626/cardiouz-2025-2-00045

The significance of the triglyceride/high-density lipoprotein cholesterol index as a predictor of major cardiovascular events
type: item
description: Aim. To study the influence of the TG/HDL-C index on the development of major cardiovascular events in patients with coronary artery disease. Materials and methods. The study included 221 patients with a diagnosis of coronary artery disease, progressive angina pectoris, hospitalized in the department of coronary heart disease and dyslipidemia. All patients were determined biochemical parameters and imaging markers. Results. When comparing patients with and without metabolic syndrome, the latter had a higher TG/HDL-C index (p<0.001), as well as CVD (p<0.001). In addition, a 3-year follow-up showed that an increase in TG/HDL-C above a certain point (Yuden index 5.1) with a statistically significant result led to a more frequent development of MACE (p<0.001), revascularization (p<0.05). Based on the results of the study, a multiple logistic regression model was built using 4 significant variables - EFT, Age, Lp(a) and TG/HDL-C. Conclusion. The triglycerides/high-density lipoprotein cholesterol index can serve as an additional criterion in the selection of lipid-lowering therapy to reduce the residual risk, with an increase in which the addition of fenofibrate should be considered.
subject: Article
  topic: section
subject: coronary artery disease
  topic: keywords
subject: cardiometabolic syndrome
  topic: keywords
subject: triglycerides
  topic: keywords
subject: high-density lipoprotein cholesterol
  topic: keywords
creator: Andrey Kim
creator: Rano Alieva
creator: Aleksandr Shek
rights: Copyright (c) 2025 А.Р. Ким, Р.Б. Алиева, А.Б. Шек (Автор) https://creativecommons.org/licenses/by/4.0
date: 2025-03-30
publication date: 2025-03-30
starting page: 29
ending page: 38
doi: 10.70626/cardiouz-2025-2-00035

The role of high-tech noninvasive cardiovisualization methods in early diagnosis and prognosis of coronary artery disease
type: item
description: Modern data on the possibilities and importance of advanced noninvasive imaging methods in the early detection of coronary artery disease (CAD) and assessment of the risk of its progression, such as multispiral computed tomographic angiography (MSCT-AG) of the coronary arteries, are systematized. The article discusses in detail the contribution of MSCT-AH to the comprehensive assessment of coronary atherosclerosis. The importance of quantitative analysis of coronary calcium as an important predictor of adverse cardiovascular events is emphasized. The possibilities of the method are discussed in the accurate assessment of the degree of coronary artery stenosis, as well as in the detailed characterization of atherosclerotic plaques, including their structure, density and detection of signs of instability. Special attention is paid to the assessment of the vascular remodeling index, which reflects adaptive or pathological changes in the vascular wall in response to plaque formation. A critically important aspect is the determination of the fractional blood flow reserve (FFR), calculated on the basis of MSCT-AG data, which makes it possible to noninvasively assess the hemodynamic significance of stenoses, which is of paramount importance in the destabilization of coronary atherosclerosis and the choice of optimal treatment tactics.
subject: Article / Review
  topic: section
subject: coronary artery disease
  topic: keywords
subject: unstable plaque
  topic: keywords
subject: early diagnosis
  topic: keywords
subject: prognosis
  topic: keywords
subject: MSCT angiography of coronary arteries
  topic: keywords
subject: coronary calcium
  topic: keywords
subject: vascular remodeling index
  topic: keywords
subject: fractional reserve of blood flow
  topic: keywords
creator: Bernara Kurbanova
creator: Feruza Abdumalikova
creator: Sabrina Zhurayeva
rights: Copyright (c) 2025 Б.Г. Курбанова, Ф.Б. Абдумаликов, С.О. Жураева (Автор) https://creativecommons.org/licenses/by/4.0
date: 2025-03-30
publication date: 2025-03-30
starting page: 71
ending page: 78
doi: 10.70626/cardiouz-2025-2-00039

Modern Approaches to Imaging Features of Unstable Atherosclerotic Plaques in the Carotid Arteries: A Literature Review
type: item
description: *]:pointer-events-auto scroll-mt-(--header-height)" dir="auto" tabindex="-1" data-turn-id="71425f87-c44c-4fa0-b8b7-d225ef83fa94" data-testid="conversation-turn-15" data-scroll-anchor="false" data-turn="user"> Carotid artery atherosclerosis is one of the leading causes of ischemic stroke and other cardiovascular complications. Rupture of an unstable atherosclerotic plaque can lead to acute cerebrovascular events, making timely diagnosis and risk assessment critically important. This review discusses current imaging methods for detecting signs of plaque instability, including magnetic resonance imaging (MRI), computed tomography (CT), positron emission tomography (PET), and ultrasound (US). Special attention is given to the diagnostic capabilities and advantages of each modality, as well as their combined use to enhance the accuracy of vascular event prediction. Research findings indicate that hybrid approaches—such as US + MRI or CT + PET—can achieve up to 93% accuracy in identifying unstable plaques. Imaging techniques provide detailed assessments of plaque morphology, lipid core, fibrous cap thickness, inflammation, and neovascularization. Advanced technologies, including elastography and artificial intelligence for image analysis, are opening new prospects for diagnosing and monitoring patients with atherosclerosis. Thus, implementing comprehensive imaging strategies enables early identification of high-risk stroke patients, improving the effectiveness of cardiovascular disease prevention and treatment. *]:pointer-events-auto [content-visibility:auto] supports-[content-visibility:auto]:[contain-intrinsic-size:auto_100lvh] scroll-mt-[calc(var(--header-height)+min(200px,max(70px,20svh)))]" dir="auto" tabindex="-1" data-turn-id="request-6906f4eb-6a98-8328-8a7e-f3b3d26d57b7-1" data-testid="conversation-turn-16" data-scroll-anchor="true" data-turn="assistant">
subject: Article / Review
  topic: section
subject: atherosclerosis
  topic: keywords
subject: unstable plaque
  topic: keywords
subject: imaging
  topic: keywords
subject: MRI
  topic: keywords
subject: ultrasound
  topic: keywords
subject: PET
  topic: keywords
subject: CT
  topic: keywords
creator: Marat Khodjibekov
creator: Feruza Bekmetova
creator: A Almanova
rights: Copyright (c) 2025 М.Х. Ходжибеков , Ф.М. Бекметова , А.Ш. Алманова (Автор) https://creativecommons.org/licenses/by/4.0
date: 2025-09-30
publication date: 2025-09-30
starting page: 235
ending page: 244
doi: 10.70626/cardiouz-2025-2-55

Vascular complications in patients with type 2 diabetes mellitus and arterial hypertension: risk factors and prevention
type: item
description: Type 2 diabetes mellitus and arterial hypertension in patients represent a significant challenge in modern medicine. The article examines the pathogenesis, clinical features, and complications of these comorbid conditions. The combination of type 2 diabetes and arterial hypertension leads to accelerated development of micro- and macrovascular complications. Prolonged elevation of blood pressure contributes to a diabetogenic effect and increases the risk of vascular complications. Key features—salt sensitivity, albuminuria, isolated systolic hypertension, and orthostatic hypotension—further complicate the situation. The authors discuss the results of recent studies on the prevention and treatment of these complications, emphasizing the importance of maintaining blood pressure within target levels and adopting an individualized therapeutic approach. Metabolic control and lifestyle modification provide additional opportunities for prevention. In conclusion, it is noted that a systemic and comprehensive approach is essential to prevent complications in patients with type 2 diabetes and arterial hypertension.
subject: Article / Review
  topic: section
subject: arterial hypertension
  topic: keywords
subject: type 2 diabetes mellitus
  topic: keywords
subject: resistant arterial hypertension
  topic: keywords
subject: circadian rhythm of arterial blood pressure
  topic: keywords
creator: Feruza Saidakbarova
creator: Nigora Srojidinova
rights: Copyright (c) 2024 https://creativecommons.org/licenses/by/4.0
date: 2024-09-22
publication date: 2024-09-22
starting page: 255
ending page: 266
doi: 10.70626/cardiouz-2024-1-00030

Comparison of the effectiveness of the original and generic forms of clopidogrel in patients with coronary artery disease (CAD).4o
type: item
description: Background. To evaluate the antiaggregation activity and clinical tolerability of Areplex (75 mg, ADAMED, Poland) compared to Plavix (75 mg, Sanofi-Winthrop Industrie, France) in CAD patients. Materials and methods. A blinded, randomized, two-parallel-group study included 40 patients with stable angina (FC I-IV). Platelet aggregation was assessed using the AP 2110 analyzer (SOLAR) with ADP (5 µmol/L) and arachidonic acid (0.5 mg/mL) inducers after a 300 mg loading dose. Results. At 24 hours post-dose, both groups showed significant reductions in aggregation degree and rate (p<0.05), with no intergroup differences (p>0.05). Safety profiles were comparable, with no adverse events reported. Conclusion. Areplex demonstrated bioequivalence to Plavix, with good tolerability, supporting its use as an effective antiplatelet agent in CAD patients.
subject: Article
  topic: section
subject: bioequivalence
  topic: keywords
subject: clopidogrel
  topic: keywords
subject: areplex
  topic: keywords
subject: plavix
  topic: keywords
subject: coronary artery disease
  topic: keywords
subject: antiplatelet therapy
  topic: keywords
creator: Guzal Mullabaeva
creator: Umid Khairullaev
rights: Copyright (c) 2025 Guzal U.Mullabaeva, Umid T.Khairullaev https://creativecommons.org/licenses/by/4.0
date: 2025-03-30
publication date: 2025-03-30
starting page: 3
ending page: 9
doi: 10.70626/cardiouz-2025-2-00032

Polypill in Cardiovascular Disease Prevention: Efficacy and Perspectives
type: item
description: Cardiovascular diseases (CVDs) are among the leading causes of morbidity and mortality worldwide. To enhance the effectiveness of prevention, the concept of a polypill containing multiple active pharmaceutical components has been introduced. This review explores the role of the polypill in primary and secondary prevention, along with its advantages and limitations. In primary prevention, the polypill may help reduce the risk of developing hypertension, dyslipidemia, and thrombosis. In secondary prevention, it aids in lowering the likelihood of recurrent cardiovascular events such as myocardial infarction and stroke. Additionally, the polypill improves medication adherence and reduces overall healthcare costs
subject: Article / Review
  topic: section
subject: Polypill
  topic: keywords
subject: arterial hypertension
  topic: keywords
subject: dyslipidemia
  topic: keywords
subject: low-density lipoprotein cholesterol
  topic: keywords
subject: atherosclerosis
  topic: keywords
subject: cardiovascular diseases
  topic: keywords
subject: prevention
  topic: keywords
subject: medication adherence
  topic: keywords
subject: stroke
  topic: keywords
subject: efficacy
  topic: keywords
creator: Shakhlo Fayzullaeva
creator: Gulnoza Khamidullaevav
creator: Guzal Abdullayeva
creator: Khafiza Yusupova
rights: Copyright (c) 2025 Ш.С. Файзуллаев, Г.А. Хамидуллаева, Г.Дж. Абдуллаева, Х.Ф. Юсупова (Автор) https://creativecommons.org/licenses/by/4.0
date: 2025-03-30
publication date: 2025-03-30
starting page: 79
ending page: 86
doi: 10.70626/cardiouz-2025-2-00040

Systematic Review of Valve Surgery with Continuous Coronary Perfusion on Beating Heart in Patients with Low Left Ventricular Ejection Fraction.
type: item
description: Aim. Beating-heart continuous coronary perfusion (BHCCP) is an alternative to cardioplegic arrest in valve surgery, potentially reducing ischemic reperfusion injury, especially in high-risk patients with low left ventricular ejection fraction (LVEF). Materials and methods. A systematic review of prospective and observational studies was conducted, focusing on BHCCP versus cardioplegia in valve surgery, with emphasis on patients with LVEF <35%. Results. Studies (e.g., Matsumoto et al., 2002) showed no significant difference in mortality or major complications, but BHCCP reduced myocardial damage markers (e.g., Troponin I, CK-MB) by 20–40% compared to cardioplegia. Clinical outcomes remained comparable across groups. Conclusion. BHCCP is a safe alternative to cardioplegia, with potential benefits in myocardial protection, though high-quality randomized trials are needed to confirm clinical superiority.
subject: Article / Review
  topic: section
subject: Continuous perfusion
  topic: keywords
subject: Beating heart
  topic: keywords
subject: Heart valves
  topic: keywords
subject: Myocardial protection
  topic: keywords
subject: Cardioplegia
  topic: keywords
creator: Umid Khayrullaev
creator: Guzal Mullabaeva
creator: Islamjan Sharipov
rights: Copyright (c) 2025 У.Т. Хайруллаев , Г.У. Муллабаева , И.М. Шарипов (Автор) https://creativecommons.org/licenses/by/4.0
date: 2025-06-30
publication date: 2025-06-30
starting page: 143
ending page: 149
doi: 10.70626/cardiouz-2025-2-00046

Cardiological approaches to the diagnosis and treatment of patients with combined atherosclerotic stenosis of the carotid and coronary arteries
type: item
description: Background. During the literature review, it becomes evident that approaches to the early diagnosis and treatment of atherosclerosis are undergoing significant changes worldwide. Unfortunately, isolated atherosclerotic involvement of a single vascular territory is rarely encountered nowadays. On the contrary, it is increasingly common to observe atherosclerotic lesions affecting multiple vascular beds in the same patient. From this perspective, modern advances in the diagnostics of multifocal atherosclerotic disease and novel approaches to the treatment of atherosclerosis have fundamentally altered the conventional understanding of this pathology. Materials and methods. Within the framework of our study, we included 105 patients examined and treated from 2019 to 2024 at the Republican Specialized Center of Surgical Angioneurology. All had hemodynamically significant stenosis of the carotid arteries and were diagnosed with either asymptomatic ischemic heart disease or stable angina pectoris (Functional Class I–II). Patients underwent both standard and specialized diagnostic procedures, including ECG, 24-hour Holter ECG monitoring, echocardiography, ultrasound examinations, CT, MRI, angiography (MSCT angiography, coronary angiography), as well as myocardial MRI stress perfusion. Results. In patients treated according to the developed algorithm, incidences of stroke, heart failure, acute coronary syndrome, and myocardial infarction were lower compared to the control group. In the main group, perioperative complications decreased to 2%, and long-term complications to 2.6%. Patient improvement was higher in the main group (53.9%) versus the control group (40.5%). A stratified approach in cases of combined carotid and coronary artery stenosis helped reduce complications and increase treatment efficacy. Conclusion. Carotid artery stenosis accompanied by asymptomatic coronary lesions most often involves two or more diseased vessels; isolated atherosclerotic processes are ra…
subject: Article
  topic: section
subject: ischemic heart disease
  topic: keywords
subject: carotid atherosclerosis
  topic: keywords
subject: coronary angiography
  topic: keywords
subject: myocardial MRI stress perfusion
  topic: keywords
creator: Shavkat Karimov
creator: Abdurasul Yo’lbarisov
creator: Doniyor Nurmatov
creator: Khodjiakbar Alidjanov
creator: Bunyodbek Nosirjonov
rights: Copyright (c) 2025 Ш.И. Каримов, А.А. Юлбарисов, Д.Х. Нурматов, Х.К. Алидижанов, Б.Т. Носиржонов (Автор) https://creativecommons.org/licenses/by/4.0
date: 2025-03-31
publication date: 2025-03-31
starting page: 10
ending page: 20
doi: 10.70626/cardiouz-2025-2-00033

Clınıcal and laboratory dıfferences between stentıng and optımal medıcal therapy ın the treatment of coronary artery dısease.
type: item
description: The objective was to study the relationship between risk factors and clinical-laboratory indicators in patients receiving treatment for ischemic heart disease with stenting and optimized medical therapy. The study included 70 patients, 37 receiving optimized medical therapy and 33 who had undergone stenting. Biochemical indicators, including cholesterol, triglyceride, and fasting glucose levels, as well as functional indicators such as ejection fraction, were analyzed. No statistically significant differences were found between the groups in terms of biochemical and functional indicators. Both treatment approaches demonstrated similar effectiveness. Stenting remains an important method of treatment, while optimized medical therapy also proves to be effective.
subject: Clinical case
  topic: section
subject: ischemic heart disease
  topic: keywords
subject: lipoproteins
  topic: keywords
subject: cardiac functional indicators
  topic: keywords
creator: Abror Abdusamatov
creator: Nargiza Nurillaeva
rights: Copyright (c) 2024 A.X. Абдусаматов, H.M. Нуриллаева (Автор) https://creativecommons.org/licenses/by/4.0
date: 2024-12-30
publication date: 2024-12-30
starting page: 241
ending page: 246
doi: 10.70626/cardiouz-2024-1-00028

Surgical treatment of post-infarction ventricular septal defect and left ventricular aneurysm
type: item
description: The article focuses on the possibilities of modern surgical interventions for conditions including post-infarction ventricular septal rupture (PIVSR) repair, left ventricular reconstruction, and coronary artery bypass grafting. Current clinical case highlights the relevance of mechanical complications of acute myocardial infarction, which, despite advances in cardiology and cardiac surgery, are still associated with high mortality. The development and standardization of surgical correction methods for these conditions, including optimal timing of surgery, remain important areas for improving treatment outcomes in patients with severe forms of myocardial infarction. The described clinical case illustrates the complexity and multi-stage process of treating patients with PIVSR, from diagnosis to the postoperative period. Data on the clinical condition, instrumental and laboratory research methods (echocardiography, coronary ventriculography), a detailed description of the performed surgical procedure, and the results of surgical intervention are presented, which can serve as a valuable guide for clinicians encountering similar cases in their practice. The need for continued accumulation of clinical material and research in this area is indicated in order to optimize the results of surgical treatment for patients in this severe category.
subject: Clinical case
  topic: section
subject: ischemic heart disease
  topic: keywords
subject: mechanical complications of myocardial infarction
  topic: keywords
subject: postinfarction ventricular septal rupture
  topic: keywords
subject: left ventricular aneurysm
  topic: keywords
subject: acute heart failure
  topic: keywords
subject: coronary artery bypass grafting
  topic: keywords
subject: ventricular septal rupture repair
  topic: keywords
subject: left ventricular reconstruction
  topic: keywords
subject: synthetic patch
  topic: keywords
creator: Komoliddin Raxmonov
creator: Davletbay Juginisov
creator: Janibek Musin
creator: Elbek Olimov
creator: Yodgor Nizamov
rights: Copyright (c) 2025 К.Х. Рахмонов , Д.Ш. Жугинисов , Д.Е. Мусин , Э.А. Олимов , Ё.У. Низамов (Автор) https://creativecommons.org/licenses/by/4.0
date: 2025-03-30
publication date: 2025-03-30
starting page: 58
ending page: 70
doi: 10.70626/cardiouz-2025-2-00038

Clinical case of pseudo-Wellens syndrome caused by pulmonary embolism
type: item
description: Pseudo-Wellens' syndrome is a rare clinical condition that mimics Wellens' syndrome. This article presents a case of pseudo-Wellens syndrome associated with pulmonary embolism (PE). A female patient was admitted to the emergency room one hour post-syncope, experiencing recurrent episodes of loss of consciousness and shortness of breath. Examination revealed elevated levels of C-reactive protein, D-dimer, interleukin-6 (IL-6), and N-terminal pro-brain natriuretic peptide (NT-proBNP). Electrocardiography (ECG) showed T-wave inversions in leads V1-V6. Coronary angiography ruled out significant stenosis, while computed tomography pulmonary angiography (CTPA) confirmed acute PE. The patient underwent fibrinolysis with 50 mg of tenecteplase. Upon discharge, the patient was recommended to take warfarin at a dose of 7.5 mg/day as anticoagulant therapy.
subject: Clinical case
  topic: section
subject: pulmonary embolism
  topic: keywords
subject: left anterior descending coronary artery
  topic: keywords
subject: pseudo-Wellens syndrome
  topic: keywords
subject: Wellens syndrome
  topic: keywords
subject: clinical case
  topic: keywords
creator: Anavar Kuvatov
creator: Sherzod Orinbaev
creator: Мalika Tursunova
creator: Feruza Zakirova
creator: Mokhinur Sadulloeva
rights: Copyright (c) 2024 А.И. Куватов, Ш.А. Оринбаев , М.У. Турсунова , Ф.А. Закирова , М.А. Садуллоева (Автор) https://creativecommons.org/licenses/by/4.0
date: 2024-12-30
publication date: 2024-12-30
starting page: 234
ending page: 240
doi: 10.70626/cardiouz-2024-1-00027

Correlation analysis of the interdependence between identified risk factors of ischemic heart disease and vitamin d levels
type: item
description: Objective. To assess the relationship between vitamin D levels and risk factors for IHD; Materials and methods. A total of 70 patients with IHD risk factors were examined and divided into groups with normal (n = 29) and deficient (n = 41) vitamin D levels. A correlation analysis of cardiovascular parameters was conducted; Results. A negative correlation was found between vitamin D levels and total cholesterol and LDL. In the control group, a correlation with diabetes mellitus was observed. No significant correlations were found in the vitamin D deficiency group; Conclusion. Vitamin D may influence lipid metabolism and IHD risk factors, but this relationship is variable and requires further research.
subject: Article
  topic: section
subject: vitamin D
  topic: keywords
subject: ischemic heart disease
  topic: keywords
subject: lipoproteins
  topic: keywords
creator: Nozimakhon Abdusamatova
creator: Nargiza Nurillaeva
rights: Copyright (c) 2025 Н.Ш. Абдусаматова, Н.М. Нуриллаева (Автор) https://creativecommons.org/licenses/by/4.0
date: 2024-12-30
publication date: 2024-12-30
starting page: 228
ending page: 233
doi: 10.70626/cardiouz-2024-1-00026