Impact of Myocardial Revascularization on Neurohormonal and Hemodynamic Parameters in Patients with Acute Myocardial Infarction
Abstract
Background. Acute myocardial infarction (AMI) remains a major cause of morbidity and mortality worldwide. The impact of myocardial revascularization on neurohormonal levels and hemodynamics in patients with AMI remains a topic of significant clinical interest.
Materials and methods. This study included 120 patients diagnosed with acute coronary syndrome with ST-segment elevation (ACSspST), with a mean age of 52.9±8.9 years. Patients were divided into two groups: Group I (89 patients) who did not undergo revascularization, and Group II (31 patients) who underwent percutaneous coronary intervention (PCI) with stenting. The study assessed neurohormonal markers NTproBNP and soluble ST2, along with echocardiographic parameters, on days 10-14 post-admission.
Results. The analysis of neurohormonal levels showed no significant difference in NTproBNP levels between the two groups. However, the NTproBNP levels were lower in the PCI group compared to the non-revascularized group. In contrast, the ST2 levels were significantly lower in the PCI group (130.8±48.6 ng/ml) compared to the non-revascularized group (196.8±58.2 ng/ml) (p<0.05). Hemodynamic parameters, such as left ventricular end-diastolic volume (EDV) and end-systolic volume (ESV), were significantly lower in the PCI group.
Conclusion. Myocardial revascularization, specifically coronary stenting, significantly improved neurohormonal parameters, particularly the soluble ST2 levels, and positively affected hemodynamic parameters, demonstrating better outcomes in patients who underwent PCI.
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