Vol. 2 No. 4 (2025): October - December
399-406
2025-12-12
Open Access

Adherence to drug therapy in patients after acute myocardial infarction: a systematic review of the literature

orcidDilshod D.Sokhibov
orcidRaisa Kh.Trigulova
orcidNilufar S.Mirakhmedova
DOI: https://doi.org/10.70626/cardiouz-2025-2-00071

Received: 2025-10-24 10:33:35

Published: 2025-12-12

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Abstract

Aim. To systematically analyze current approaches to assessing and improving medication adherence in patients after acute myocardial infarction during outpatient follow-up, with a particular focus on factors influencing treatment adherence and the role of a multidisciplinary approach.


Materials and Methods. A systematic review of the literature on medication adherence after acute myocardial infarction was conducted. Data from large international studies were analyzed, including a meta-analysis of 10 studies involving 106,002 patients, the 2023 American Heart Association scientific statement, the 2023 ESC and 2025 ACC/AHA guidelines, and current cardiac rehabilitation programs.


Results. A meta-analysis showed that good adherence to drug therapy is associated with reduced all-cause mortality (odds ratio 0.56; 95% CI: 0.45-0.69), cardiovascular mortality (OR 0.66; 95% CI: 0.51-0.87), and hospitalization rates (OR 0.61; 95% CI: 0.45-0.82). Non-adherence to therapy occurs in 30% of patients after myocardial infarction. Shared decision making, structured cardiac rehabilitation programs, and the involvement of multidisciplinary teams significantly improve long-term treatment adherence.


Conclusion. Adherence to drug therapy is a key factor in improving the prognosis of patients after acute myocardial infarction. A multidisciplinary approach, including shared decision making, patient education, pharmaceutical counseling, and the use of digital technologies, demonstrates the greatest effectiveness in improving adherence.

Keywords

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About the Authors

Dilshod D.Sokhibov
dsohibov97@gmail.com
Republican Specialized Scientific and Practical Medical Center of Cardiology

Department of X-ray endovascular treatment of cardiovascular diseases, Republican Specialized Scientific and Practical Medical Center of Cardiology, basic doctoral student

Raisa Kh.Trigulova
trigulovaraisa@gmail.com
Republican Specialized Cardiology Scientific-Practical Medicine center

Department of X-ray endovascular treatment of cardiovascular diseases, Republican Specialized Scientific and Practical Medical Center of Cardiology, Head of the Laboratory of Preventive Cardiology, Doctor of Medical Sciences, Professor

Nilufar S.Mirakhmedova
mirakhmedovanilufar66@gmail.com
Republican Specialized Cardiology Scientific-Practical Medicine center

Republican Specialized Scientific and Practical Medical Center of Cardiology, basic doctoral studen

License

Copyright (c) 2025 Д.Д. Сохибов , Р.Х. Тригулова , Н.С. Мирахмедова (Автор)

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This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

Adherence to drug therapy in patients after acute myocardial infarction: a systematic review of the literature. (2025). CARDIOLOGY OF UZBEKISTAN, 2(4), 399-406. https://doi.org/10.70626/cardiouz-2025-2-00071
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