Angiotenzin ayiruvchi ferment geni polimorfizmining peripartum kardiomiopatiya prognoziga ta'siri
Annotatsiya
Kirish. Peripartum kardiomiopatiya (PPKM) kam uchraydigan, ammo hayot uchun xavfli bo‘lishi mumkin bo‘lgan yurak yetishmovchiligi bilan bog‘liq kasallikdir. Angiotenzin ayiruvchi ferment (ACE) geni polimorfizmi kabi genetik omillar kasallik kechishiga ta’sir qilishi mumkin.
Materiallar va usullar. Tadqiqotda 102 nafar PPKM bilan og‘rigan bemor va 65 nafar sog‘lom ayol ishtirok etdi. ACE I/D polimorfizmining genotiplanishi PCR usuli yordamida amalga oshirildi. Klinik, funktsional va exokardiyografik parametrlar baholandi.
Natijalar. 11 (10,8%) bemorda funktsional II sinf, 64 (62,7%) bemorda III sinf va 27 (26,5%) bemorda IV sinf aniqlandi. I/D genotiplari taqsimoti: DD – 24 (23,5%), ID – 45 (44,1%), II – 33 (32,3%). DD genotipiga ega bemorlarda chap qorinchaning chiqarib tashlash fraksiyasi (LVEF) pastroq bo‘lib, diastolik va sistolik yurak o‘lchamlari yuqoriroq bo‘ldi. Ikki yillik kuzatuv davomida kasallikning zo‘rayishi natijasida DD va ID subguruhlarida o‘lim darajasi 5% ni, II subguruhda esa 0% ni tashkil etdi.
Xulosa. ACE geni I/D polimorfizmi PPKM bilan og‘rigan bemorlarda chap qorinchaning sistolik va diastolik funktsiyasiga ta’sir ko‘rsatishi mumkin. D alleliga va DD genotipiga ega bo‘lgan bemorlarning prognozi salbiyroq hisoblanadi.
Kalit so‘zlar:
Mualliflar haqida
Adabiyotlar ro'yxati
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