Clinical and functional characteristics of life support systems during and after coronary artery bypass grafting
Abstract
Aim. To evaluate the clinical and functional characteristics of vital systems during and after coronary artery bypass grafting.
Materials and methods. This study included 160 patients who underwent CABG with and without cardiopulmonary bypass at the Samarkand branch of the Republican Specialized Scientific-Practical Medical Center of Cardiology (2020–2026). Patients were divided into two groups: the main group (n=80), where an individualized algorithm using a multifactorial prognostic scale and ulinastatin was applied, and the control group (n=80), where standard management was used. Hemodynamic monitoring included HR, mean arterial pressure, CVP, stroke and cardiac indices, ejection fraction, cardiac output, and SVR across six stages from admission to discharge.
Results. The main group showed improved outcomes: reduced myocardial afterload, stabilized HR and pressure, enhanced cardiac performance, and a shift from hypodynamic to eukinetic circulation.
Conclusion. In high-risk patients, this approach reduced complication rates and ICU stay. An individualized strategy with ulinastatin ensures a more stable perioperative course and lowers complication risk.
About the Authors
List of references
Aliev M., Zhumadilov Zh.Sh., Seidalin A.O., Zhumadilov A.Sh., Akimzhanov K.D., Simakov G.L. A system for multifactorial computer prediction of the development of low cardiac output syndrome in cardiac surgery. Certificate of State Registration of Intellectual Property Object, No. 188, 27 March 2007. In Russian: Алиев М., Жумадилов Ж.Ш., Сейдалин А.О., Жумадилов А.Ш., Акимжанов К.Д., Симаков Г.Л. Система многофакторного компьютерного прогнозирования развития синдрома низкого сердечного выброса в кардиохирургии. Свидетельство о гос. регистрации объекта интеллектуальной собственности. №188, 27.03.2007.
Bokeriya L.A., Gordeev M.L., Avaliani V.M. Off-pump coronary artery bypass grafting: a modern approach. Thoracic and Cardiovascular Surgery. 2013, 4, 4–15. In Russian: Бокерия Л.А., Гордеев М.Л., Авалиани В.М. Аортокоронарное шунтирование на работающем сердце: современный взгляд на проблему. Грудная и сердечно-сосудистая хирургия. 2013; 4:4–15.
Gorbachevskii S.V., Shmal’ts A.A., Grenaderov M.A., et al. Surgical treatment of borderline conditions in patients with cardiovascular diseases complicated by pulmonary hypertension. Bulletin of the A.N. Bakulev Scientific Center for Cardiovascular Surgery, Russian Academy of Medical Sciences. 2017, 18, 1, 73–80. In Russian: Горбачевский С.В., Шмальц А.А., Гренадеров М.А. и соавт. Хирургическое лечение пограничных состояний у больных с заболеваниями сердечно-сосудистой системы, осложнённых лёгочной гипертензией. Бюллетень НЦССХ им. А.Н. Бакулева РАМН. 2017;18(1):73–80.
Gubler E.V. Computational methods for analysis and recognition of pathological processes. Moscow: Meditsina 1978; p. 296. In Russian: Гублер Е.В. Вычислительные методы анализа и распознавания патологических процессов. Москва: Медицина; 1978. С. 296.
Kamenskaya O.V., Klinkova A.S., Meshkov I.O., Lomivorotov V.V., et al. Predictors of the development of cardiorespiratory complications in patients with coronary artery disease undergoing coronary artery bypass grafting. Cardiology. 2017, 4, 5–9. In Russian: Каменская О.В., Клинкова А.С., Мешков И.О., Ломиворотов В.В. и др. Предикторы развития кардиореспираторных осложнений у больных ИБС при АКШ. Кардиология. 2017;4:5–9.
Matlubov M.M., Clinical and functional justification for the choice of optimal anesthetic tactics during childbirth in obese patients. Diss. Doctor of Medical Sciences, Tashkent; Uzbekistan, 2018; p. 25. In Russian: Матлубов М.М. Клинико-функциональное обоснование выбора оптимальной анестезиологической тактики при родоразрешении у пациентов с ожирением. Дисс. докт. мед. наук. Ташкент; 2018. 25 с.
Matlubov M.M., Yusupov J.T. Improving anti-inflammatory therapy for patients after CABG. J. Biomed. Pract. 2024, 9, 1, 256–262. In Russian: Матлубов М.М., Юсупов Ж.Т. Усовершенствование противовос- палительной терапии больным после АКШ. Journal of Biomedicine and Practice. 2024;9(1):256–262.
Matlubov M.M., Yusupov J.T., Nizamov Kh.Sh. Optimization of intensive care for patients after coronary artery bypass grafting. Problems of Biology and Medicine. 2024, 151, 1, 479–484. In Russian: Матлубов М.М., Юсупов Ж.Т., Низамов Х.Ш. Оптимизация интенсивной терапии больным после АКШ. Биология ва тиббиёт муаммолари. 2024;151(1):479–484.
Matlubov M.M., Yusupov J.T., Saidov M.A., Zhoniyev S.Sh., Mallaev I.U. The role of artificial circulation in the development of postoperative cognitive dysfunction. J. Cardiorespir. Res. 2022, 3, 4, 15–20. In Russian: Матлубов М.М., Юсупов Ж.Т., Саидов М.А., Жониев С.Ш., Маллаев И.У. Роль искус- ственного кровообращения в развитии послеоперационной когнитивной дисфункции. Journal of Cardiorespiratory Research. 2022;3(4):15–20.
Khromushin V.A., Buchel’ V.F., Zherebtsova, V.A., Chestnova T.V. A program for constructing algebraic models of constructive logic in biophysics, biology, and medicine. Bulletin of New Medical Technologies. 2008, XV, 4, 173–174. In Russian: Хромушин В.А., Бучель В.Ф., Жеребцова В.А., Честнова Т.В. Программа построения алгебраических моделей конструктивной логики в биофизике, биологии, медицине. Вестник новых медицинских технологий. 2008;15(4):173–174.
Copyright (c) 2025 Ж.Т. Юсупов, М.М. Матлубов , Э.Г. Хамдамова (Автор)
This work is licensed under a Creative Commons Attribution 4.0 International License.