The impact of revascularizatıon vıa stenting on left ventricular ejection fraction ın patients with myocardial infarction
Abstract
Aim. To evaluate the one-year dynamic effect of complete or incomplete revascularization on left ventricular ejection fraction (LVEF) in patients with a history of myocardial infarction (MI) who have preserved or mildly reduced LVEF.
Materials and methods. The study included 270 patients with a history of MI. All patients underwent transthoracic echocardiography and coronary angiography (CAG) based on clinical examination findings. Depending on the number of affected atherosclerotic coronary vessels and the extent of stenting performed, patients were divided into three groups: Complete revascularization (CR) (n=115), Incomplete revascularization (IR) (n=94), and No revascularization (NR) (n=61). After the procedure, all patients were discharged with standard treatment. After one year, follow-up echocardiographic assessment of LVEF was performed.
Results. In the CR group, LVEF increased significantly from 54.0 [47.0; 59.7] to 55.7 [46.9; 61.4] (p = 0.017). In the IR group, LVEF increased from 53.9 [43.7; 56.4] to 55.7 [46.9; 61.4], but the change was not statistically significant (p = 0.458). In the NR group, LVEF decreased from 50.7 [45.0; 56.3] to 48.2 [41.8; 54.3] (p = 0.011). No statistically significant differences were observed between groups in terms of diastolic function parameters of the left ventricle.
Conclusion. In post-infarction patients, complete anatomical revascularization of affected coronary arteries via stenting has a significantly positive impact on the improvement of LVEF.
About the Authors
List of references
Feng S, Li M, Fei J, et al. Ten-year outcomes after percutaneous coronary intervention versus coronary artery bypass grafting for multivessel or left main coronary artery disease: A systematic review and meta-analysis. J Cardiothorac Surg. 2023;18:54. https://doi.org/10.1186/s13019-023-02101-y.
Raja SG, Ilsley C, De Robertis F, Lane R, et al. Mid-to-long term mortality following surgical versus percutaneous coronary revascularization stratified according to stent subtype: An analysis of 6,682 patients with multivessel disease. PLoS One. 2018;13(2):e0191554. https://doi.org/10.1371/journal.pone.019155 4.
Bajraktari G, Bytyçi I, Henein MY, Alfonso F, Ahmed A, Jashari H, Bhatt DL. Complete revascularization for patients with multivessel coronary artery disease and ST-segment elevation myocardial infarction after the COMPLETE trial: A meta-analysis of randomized controlled trials. Int J Cardiol Heart Vasc. 2020;29:100549. https://doi.org/10.1016/j.ijcha.2020.100549.
Bruno F, Marengo G, De Filippo O, Wanha W, Leonardi S, et al. Impact of complete revascularization on development of heart failure in patients with acute coronary syndrome and multivessel disease: A subanalysis of the CORALYS Registry. J Am Heart Assoc. 2023;12(15):e028475. https://doi.org/10.116 1/JAHA.122.028475.
Carson P, Wertheimer J, Miller A, O’Connor CM, Pina IL, Selzman C, et al. The STICH trial (surgical treatment for ischemic heart failure): Mode-of-death results. JACC Heart Fail. 2013;1:400–407. https://doi.org/10.1016/j.jchf.2013.04.006.
Holmes DR Jr, Davis KB, Mock MB, Fisher LD, Gersh BJ, Killip T 3rd, et al. The effect of medical and surgical treatment on subsequent sudden cardiac death in patients with coronary artery disease: A report from the Coronary Artery Surgery Study. Circulation. 1986;73:1254–1263. https://doi.org/10.1161/01.CIR.73.6.1254.
Huang D, Huo Y, Zhang S, Huang C, Han Y. Prevention of sudden cardiac death after revascularization for coronary heart disease. Int J Heart Rhythm. 2018;3:1–15. https://doi.org/10.3760/cma.j.issn.2095-4 279.2018.01.001.
Kurbanov RD, Mullabaeva GU, Irisov JB. The influence of myocardial revascularization on ventricular arrhythmia in patients with ischemic heart disease. Med Sci. 2017;21(1):103–106.
Zeppenfeld K, Tfelt-Hansen J, de Riva M, Winkel BG, Behr ER, Blom NA, et al. 2022 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. Eur Heart J. 2022;43(40):3997–4126. https://doi.org/10.1093/eurheartj/ehac262.
Bhat A, Gan GC, Tan TC, Hsu C, Denniss AR. Myocardial viability: From proof of concept to clinical practice. Cardiol Res Pract. 2016;2016:1020818. https://doi.org/10.1155/2016/1020818.
Cleland JG, Calvert M, Freemantle N, Arrow Y, Ball SG, Bonser RS, et al. The Heart Failure Revascularisation Trial (HEART). Eur J Heart Fail. 2011;13(2):227–233. https://doi.org/10.1093/eurjhf/ hfq230.
Effect of PCI on health status in ischemic left ventricular dysfunction: Insights from REVIVED-BCIS2. JACC Heart Fail. 2024;12(4):345–354. https://doi.org/10.1016/j.jchf.2024.03.010.
Ndrepepa G, Cassese S, Byrne RA, Bevapi B, et al. Left ventricular ejection fraction change following percutaneous coronary intervention: Correlates and association with prognosis. J Am Heart Assoc. 2024;13(21):e035791. https://doi.org/10.1161/JAHA.124.035791.
Wollmuth J, Patel MP, Dahle T, Bharadwaj A, et al. RESTORE-EF Investigators. Ejection fraction improvement following contemporary high-risk percutaneous coronary intervention: RESTORE-EF study results. J Soc Cardiovasc Angiogr Interv. 2022;1(5):100350. https://doi.org/10.1016/j.jscai.2022.100350.
Bista R, Zghouzi M, Jasti M, Lichaa H, Kerrigan J, et al. Outcomes of percutaneous revascularization in severe ischemic left ventricular dysfunction. Curr Cardiol Rep. 2024;26(5):435–442. https://doi.org/10.1 007/s11886-024-02045-2.
Neumann FJ, Sousa-Uva M, Ahlsson A, Alfonso F, et al. 2018 ESC/EACTS Guidelines on myocardial revascularization: The Task Force on myocardial revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J. 2019;40(2):87–165. https://doi.org/10.1093/eurheartj/ehy394.
Mehta SR, Wood DA, Storey RF, Mehran R, Bainey KR, Nguyen H, et al. COMPLETE Trial Steering Committee and Investigators. Complete revascularization with multivessel PCI for myocardial infarction. N Engl J Med. 2019;381(15):1411–1421. https://doi.org/10.1056/NEJMoa1907775.
Boeken U, Feindt P, Litmathe J, Gams E. Comparison of complete and incomplete revascularization in CABG patients with severely impaired left ventricular function. Z Kardiol. 2004;93(3):216–221. https://doi.org/10.1007/s00392-004-0043-y.
Saraste A, Maaniitty T. Significance of myocardial flow reserve after revascularization. Eur Heart J Cardiovasc Imaging. 2023;24(11):1478–1479. https://doi.org/10.1093/ehjci/jead151.
Ruppar TM, Cooper PS, Mehr DR, Delgado JM, Dunbar-Jacob JM. Medication adherence interventions improve heart failure mortality and readmission rates: Systematic review and meta-analysis of controlled trials. J Am Heart Assoc. 2016;5(6):e002606. https://doi.org/10.1161/JAHA.115.002606.
Üveges Á, Jenei C, Kiss T, et al. Three-dimensional evaluation of the spatial morphology of stented coronary artery segments in relation to restenosis. Int J Cardiovasc Imaging. 2019;35(10):1755–1763. https://doi.org/10.1007/s10554-019-01628-3.
Copyright (c) 2025 Э.Я. Турсунов, Р.Д. Курбанов, Н.У. Закиров (Автор)

This work is licensed under a Creative Commons Attribution 4.0 International License.