Epikardial yog' qatlami yurak-qon tomir kasalliklarida prognostik belgi sifatida
Annotatsiya
Dunyo bo‘yicha o‘limning asosiy sababi yurak-qon tomir kasalliklari (YQTK) hisoblanadi. Ma’lum YQTKga olib keluvchi omillardan tashqari, so‘nggi yillarda kardiyometabolik sindrom komponentlaridan biri sifatida semirishga katta e’tibor qaratilmoqda. Bu holatda, visseral semizlik yurakning turli patologiyalari, jumladan, miokard ishemiyasi, yurak aritmiyalari paydo bo‘lishi, shuningdek, surunkali yurak yetishmovchiligi rivojlanishi yoki uning kuchayishiga xizmat qiladi. Yog‘ to‘qimasi to‘planadigan odatiy joylardan tashqari, YQTK rivojlanishiga bevosita hissa qo‘shuvchi maxsus soha mavjud — bu epikardial yog‘ qatlami (EYoQ). Normal holatda EYoQ mexanik to‘siq vazifasini bajarib, yurakni tashqi ta’sirlardan himoya qiladi. Ammo uning ortiqcha to‘planishi natijasida har qanday yog‘ to‘qimasi lokalizatsiyasida rivojlanadigan meta-yallig‘lanish jarayoni yuzaga keladi, bu esa provosplamator sitokinlarning ajralishi va endotelial disfunksiyaning buzilishiga olib keladi hamda beqarorlikni qo‘zg‘atuvchi omil sifatida xizmat qiladi.
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