Peripartal kardiomiopatiyalarda qorinchalar aritmiyalarining yurak patologik remodellanishi bilan o‘zaro bog‘liqligi
Qabul qilingan: 2024-12-18 17:37:29
Nashr etilgan: 2024-03-29
Annotatsiya
Maqsad. Peripartal kardiomiopatiya (PKMP) — homiladorlikning kech davrlari yoki tug‘ruqdan keyingi davrda ayollarda uchraydigan, kam uchraydigan, ammo jiddiy asoratlarga olib keladigan kasallikdir. Bu holat ko‘pincha qorinchalar aritmiyalari va yurakning patologik remodellanishi bilan kechadi. Tadqiqotning maqsadi PKMP bilan kasallangan bemorlarda qorinchalar aritmiyalari va yurakning patologik remodellanishi o‘rtasidagi bog‘liqlikni baholash hamda kasallikni boshqarish va prognoz qilish uchun klinik ahamiyatni yoritishdir.
Materiallar va usullar. Tadqiqotga 1997–2022 yillar oralig‘ida Respublika ixtisoslashgan kardiologiya ilmiy-amaliy tibbiyot markazida PKMP tashxisi bilan davolangan 104 bemor kiritildi. Bemorlar chap qorinchalar otish fraksiyasi (ChQOF) bo‘yicha ikki guruhga bo‘lindi: I guruh (ChQOF <35%) va II guruh (ChQOF 36-45%). Diagnostika Evropa kardiologlar jamiyatining tavsiyalariga asoslangan. Tekshiruvlar EKG, ekokardiografiya, sutkalik EKG monitoringi va klinik baholashni o‘z ichiga olgan. Statistik tahlillar tavsifiy va farqlovchi usullardan foydalangan holda amalga oshirildi.
Natijalar. Bemorlarning o‘rtacha yoshi 30,15±2,9 yoshni tashkil etdi. Kasallik holatlarining aksariyati (76%) tug‘ruqdan keyingi davrda aniqlangan, ulardan 49% birinchi uch oy ichida tashxis qo‘yilgan. Qorinchalar aritmiyalari, ayniqsa, yuqori gradatsiyalar (Laun bo‘yicha III, IVA, IVB), I guruhda II guruhga qaraganda sezilarli darajada ko‘p uchradi. Yurakning og‘ir patologik remodellanishi, jumladan, chap qorinchalarning diastolik va sistolik hajmlari, I guruhda 10% ko‘proq qayd etildi. Bundan tashqari, I guruh bemorlarida gipertoniya va kuchli sinusli taxikardiya ko‘proq uchraganligi kuzatildi.
Xulosa. Tadqiqot natijalari shuni ko‘rsatadiki, ChQOF <35% bo‘lgan PKMP bemorlarida qorinchalar aritmiyalari va yurakning patologik remodellanishi o‘rtasida kuchli bog‘liqlik mavjud. Bu natijalar PKMPni boshqarishda aritmiyalarni erta aniqlash va moslashgan davolash strategiyalarining ahamiyatini ta’kidlaydi.
Kalit so‘zlar
Adabiyotlar ro'yxati
-
Kazantseva V.D., Honigberg M.C., Givertz M.M., Simpson C., Key findings in peripartum cardiomyopathy, J Cardiol, 2021, 23, 04, 215–223.
-
Abdullaev T.A., Kurbanov N.A., Mirzarakhimova S.T., Tsoi I.A., Peripartum cardiomyopathy, Journal of Heart Failure, 2016, 17, 05, 350–356, 10.18087/rhfj.2016.5.2256.
-
Iha N., Iha A.K., Stergiopoulos K., Lima F.V., Cunningham F.J., Contemporary perspectives on peripartum cardiomyopathy, Int J Cardiol, 2019
-
Main, E. K., McCain, C. L., Morton, C. H., Pregnancy-related mortality in California: causes, characteristics, and improvement opportunities, Obstet Gynecol, 2015, 125, 938–947.
-
Duncker D., Westenfeld R., Konrad T., Risk for life-threatening arrhythmia in newly diagnosed peripartum cardiomyopathy with low ejection fraction: a German multi-centre analysis, Clin Res Cardiol, 2017, 106, 08, 582–589, 10.1007/s00392-017-1090-5.
-
Abdullaev T.A., Tsoi I.A., Khudoiberganov O.K., Mirzarakhimova S.T., Five-year prognosis of patients with peripartum cardiomyopathy, Cardiology Bulletin, 2022, 17, 03, 58–62.
-
Hilfiker D.Kleiner., Haghikia A., Nonhoff J., Bauersachs J., Peripartum cardiomyopathy: current management and future perspectives, Eur Heart J, 2015, 36, 018, 1090–1097, 10.1093/eurheartj/ehv009.
-
Hilfiker D.Kleiner., Haghikia A., Nonhoff J., Bauersachs J., Peripartum cardiomyopathy: current management and future perspectives, Eur Heart J, 2015, 36, 018, 1090–1097, 10.1093/eurheartj/ehv009.
-
Pillarisetti J., Kondur A., Alani A., Peripartum cardiomyopathy: predictors of recovery and current state of implantable cardioverter-defibrillator use, J Am Coll Cardiol, 2014, 63, 025 Pt A, 2831–2839.
-
Mallikethi S.Reddy., Akintoye E., Trehan N., Burden of arrhythmias in peripartum cardiomyopathy: Analysis of 9841 hospitalizations, Int J Cardiol, 2017, 235, 114–117.
-
Duncker D., Pfeffer T.J., Bauersachs J., Veltmann C., ECG and arrhythmias in peripartum cardiomyopathy, Herzschrittmacherther Elektrophysiol, 2021, 32, 02, 207–213.
-
Laghari A.H., Khan A.H., Kazmi K.A., Peripartum cardiomyopathy: ten-year experience at a tertiary care hospital in Pakistan, BMC Res Notes, 2013, 6, 495.
-
Duncker D., Westenfeld R., Konrad T., Risk for life-threatening arrhythmia in newly diagnosed peripartum cardiomyopathy with low ejection fraction: a German multi-centre analysis, Clin Res Cardiol, 2017, 106, 08, 582–589, 10.1007/s00392-017-1090-5.
-
Abdullaev T.A., Khudoiberganov O.K., Mirzarakhimova S.T., Tsoi, I. A., Frequency and nature of rhythm and conduction disturbances in relation to heart remodeling features in patients with peripartum cardiomyopathy, Society and Innovation, 2022, 3, 134–141.
Mualliflar haqida
Igor A.Tsoi
Saodat. T.Mirzarakhimova
Litsenziya
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Qanday iqtibos keltirish kerak
