Роль генетического полиморфизма PAI-1 4G/5G в развитии коронарной болезни сердца.
Получена: 2025-02-20 12:58:16
Опубликована: 2024-12-30
Аннотация
Background. The PAI-1 4G/5G genetic polymorphism plays an important role in the regulation of fibrinolysis and susceptibility to coronary artery disease (CAD). PAI-1 regulates the rate of thrombus destruction by limiting excessive plasminogen activation. Elevated PAI-1 levels play a key role in preventing both excessive thrombus formation and hyperfibrinolysis, which can lead to bleeding. An increase in PAI-1 promotes atherogenesis by reducing fibrinolysis and promoting the formation of stable atherosclerotic plaques, as well as vascular inflammation, which accelerates the progression of atherosclerosis.
Materials and methods. A comprehensive analysis of literature data, clinical studies, and meta- analyses over the past 10 years related to the genetic polymorphism PAI-1 4G/5G was conducted.
Results and conclusion. Literature data and various studies indicate a significant role of the genetic polymorphism PAI-1 4G/5G in the development of cardiovascular diseases.
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Список литературы
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Copyright (c) 2025 Рано А. Курбанова, Андрей Р. Ким, Александр Б. Шек (Автор)

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