Prolaktinning peripartal kardiomiopatiyadagi ventrikulyar aritmiyalarga ta'siri: klinik tadqiqot
Annotatsiya
Maqsad: Peripartal kardiomiopatiya (PKMP) bilan kasallangan bemorlarda yurak ritmi buzilishlarining chastotasi va xususiyatlarini yurakni qayta qurish va qon prolaktin darajasi bilan bog'liq holda baholash.
Materiallar va metodlar: Tadqiqotga PKMP tashxisi tasdiqlangan 104 bemor kiritildi, tashxis 1995 yilgi WHO tavsiyalariga va 2010 yilgi Peripartal Kardiomiopatiya bo'yicha Ishchi Guruh (Yurak Yetishmovchiligi Assotsiatsiyasi EOK) tavsiyalariga muvofiq belgilandi. Barcha bemorlar yurak yetishmovchiligi (YY) uchun optimallashtirilgan farmakologik terapiya oldilar. Bemorlar prolaktin darajasiga qarab ikki guruhga ajratildi: Guruh I – prolaktin darajasi 496 uU/ml dan yuqori bo'lgan 30 bemor (o'rtacha 612,2±65,9 uU/ml), Guruh II – prolaktin darajasi 496 uU/ml dan past bo'lgan 74 bemor (o'rtacha 236,3±75,9 uU/ml).
Prolaktin darajasini aniqlash uchun qon namunalarini yurak yetishmovchiligi klinik simptomlari namoyon bo'lgan paytda, kasalxonaga yotqizilishdan tortib, tug'ruhdan keyingi 3-4 oygacha bo'lgan davrda olishdi.
Natijalar: Taqqoslash tahlili shuni ko'rsatdiki, chap qorinchadagi ritm buzilishlarining umumiy soni (CQRB) ikkala guruhda ham o'xshash bo'lib, Guruh I da 456,9±215,89 holat/kun, Guruh II da esa 398,69±315,89 holat/kun (p>0,05)ni tashkil etdi. Ikkala guruhda ham kun davomida ventrikulyar ektopik faoliyat ko'proq uchradi, kun/tun nisbati Guruh I da 1,34±0,3 va Guruh II da 1,5±0,44 (p>0,05) bo'ldi.
Xulosa: Olingan ma'lumotlar shuni ko'rsatadiki, prolaktin darajasi yuqori bo'lgan PKMP bemorlari ancha tez-tez va murakkab ventrikulyar ekstrasistoliyalarga duch keladilar, bu bemorlarning prognozini baholashda prognoz ko'rsatkichi sifatida muhim ahamiyatga ega bo'lishi mumkin. Prolaktin darajasining PKMP bemorlarida ventrikulyar aritmiyalarni boshqarishda prognoz qiymatini o'rganish uchun qo'shimcha tadqiqotlar olib borish zarur.
Mualliflar haqida
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Copyright (c) 2024 О.К. Худойберганов, Т.А. Абдуллаев , И.А. Цой , С.Т. Мирзарахимова , Н.Х. Пазилжанов (Автор)
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