Yosh aholi (1--35 yosh) orasida to‘satdan yurak o‘limi qurbonlarida geneologik shajaralash metodining klinik ahamiyati
Qabul qilingan: 2026-05-03
Nashr etilgan: 2026-06-29
Annotatsiya
Maqsad. Yosh aholi (1-35 yosh) orasida to‘satdan yurak o‘limi qurbonlarining 1-2 va 3 darajali qarindoshlarida geneologik shajaralash metodining natijalarini baholash.
Material va usullar. Tadqiqotda 24 nafar to‘satdan yurak o‘limi (TYuO‘) qurbonlarining 1–3 darajali qarindoshlarida irsiy omillarni baholash maqsadida klinik-genealogik (shajara) usuli qo‘llanildi. Tahlil probanddan boshlanib, 3–4 avlodni qamrab oldi. Ma’lumotlar standartlashtirilgan intervyu, tibbiy hujjatlar va klinik ma’lumotlar asosida yig‘ildi. Har bir oila a’zosi bo‘yicha jins, yosh, tashxis, kasallik debyuti, to‘satdan o‘lim holatlari va qarindoshlik nikohi haqida ma’lumotlar qayd etildi. Shajaralar xalqaro genetik nomenklatura asosida tuzilib, kasallikning avlodlar bo‘ylab tarqalishi, meroslanish tipi va fenotipik xususiyatlari baholandi.
Natijalar. Natijalariga ko‘ra, TYuO‘ chastotasi avlodlar kesimida farq qilib, yosh omillari bilan bog‘liq ekani aniqlandi. I avlodda (bobo-buvilar) TYuO‘ eng yuqori – 3,2% ni tashkil etdi, II avlodda 2,1% gacha kamaydi, keyingi avlodlarda esa juda past ko‘rsatkichlarda qayd etildi. III avlodda (ota-ona) TYuO‘ kuzatilmagan bo‘lsa-da, klinik simptomlar (aritmiya, sinkope) mavjudligi subklinik yurak patologiyasi ehtimolini ko‘rsatdi. Siblinglarda TYuO‘ 1,3% qayd etilib, yoshga nisbatan erta namoyon bo‘lishi oilaviy moyillikni tasdiqlaydi . Statistik jihatdan ko‘pchilik guruhlar o‘rtasida ishonchli farq aniqlanmadi (p > 0,05), bu namuna hajmining cheklanganligi bilan izohlanadi.
Xulosa. Natijalar TYuO‘da oilaviy-irsiy omillar muhim o‘rin tutishini ko‘rsatdi. Geneologik
shajaralash yuqori xavfli shaxslarni erta aniqlashda samarali skrining usuli hisoblanadi. Natijalar ishonchliligini oshirish uchun kengroq popklyatsiyada tadqiqotlar olib borish talab etiladi.
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