Jild 3 № 3 (2026): Iyul - sentyabr
22-30
2026-09-30
Ochiq kirish

Dasturiy gemodializdagi 2-tip qandli diabetli bemorlarda glikemik nazoratning miokardial stressni bașorat qilișdagi ahamiyati

Lola T.Daminova
Sitoraxon U.Muminova
Xurshida K.Nasirova
Rano B.Alieva
Barkamol U.Jumaboeva
https://doi.org/10.70626/cardiouz-2026-3-00095

Qabul qilingan: 2026-07-03

Nashr etilgan: 2026-09-30

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Annotatsiya

Dolzarbligi. 2-tur qandli diabet (QD2) bilan kasallangan va dasturiy gemodializ muolajasini olayotgan bemorlar yurak-qon tomir asoratlari rivojlanişi böyiça yuqori xavf guruhiga mansub hisoblanadi. Surunkali giperglikemiya yalliğlaniş jarayonlari, oksidativ stress, endotelial disfunksiya hamda yurakning patologik remodellanişi orqali miokard şikastlanişini kuçaytiradi. Miya natriyuretik peptidining N-terminal fragmenti (NT-proBNP) miokardial stress va yurak-qon tomir xavfini baholaşda muhim biomarker hisoblanadi.


Tadqiqot maqsadi. Dasturiy gemodializ olayotgan diabetik nefropatiyali bemorlarda glikemik nazorat hamda NT-proBNP darajasi örtasidagi özaro boğliqlikni baholaş.


Materiallar va usullar. Bir vaqtning özida ötkazilgan tadqiqotga dasturiy gemodializ olayotgan (SBE 5D bosqiç) va diabetik nefropatiyali 60 nafar bemor kiritildi. Glikirlangan gemoglobin (HbA1c) darajasiga köra bemorlar ikki guruhga ajratildi: HbA1c <7,0% (n=26) va HbA1c ≥7,0% (n=34). NT-proBNP darajasi baholandi va guruhlar örtasida taqqoslandi. HbA1c va NT-proBNP örtasidagi boğliqlikni baholaş uçun Spirmen korrelyatsion tahlili qöllanildi. NT-proBNP oşişining mustaqil prediktorlarini aniql aş uçun logistik regressiya tahlili ötkazildi.


Natijalar. HbA1c ≥7,0% bölgan bemorlarda NT-proBNP darajasi HbA1c <7,0% guruhiga nisbatan statistik ahamiyatli darajada yuqori böldi (628,3 ga qarşi 549,5 pg/ml; p=0,04). Qoniqarsiz glikemik nazorat guruhida HbA1c va NT-proBNP örtasida örtaça musbat korrelyatsiya aniqlandi (r=0,34; p=0,049). Logistik regressiya tahliliga köra, HbA1c NT-proBNP oşişining mustaqil prediktori ekanligi aniqlandi (OR=1,45; 95% IO 1,02–2,05; p=0,04). Olingan natijalar asosida HbA1c va NT-proBNP körsatkiçlariga asoslangan yurak-qon tomir xavfini üç bosqiçli stratifikatsiya qiliş algoritmi taklif etildi.


Xulosa. Qoniqarsiz glikemik nazorat dasturiy gemodializ olayotgan va diabetik nefropatiyali bemorlarda NT-proBNP darajasining oşişi bilan boğliq. HbA1c uşbu populyatsiyada miokardial stress va yurak-qon tomir xavfining mustaqil prediktori sifatida qaralişi mumkin. HbA1c va NT-proBNP ni kompleks baholaş yurak-qon tomir xavfini stratifikatsiya qilişni yaxşilaydi hamda davolaş taktikasini optimallaştirişga xizmat qiladi.

Kalit so‘zlar

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Mualliflar haqida

Lola T.Daminova
dr.daminova@gmail.com
Toshkent davlat tibbiyot universiteti
Sitoraxon U.Muminova
dr.muminova@gmail.com
Toshkent davlat tibbiyot universiteti
Xurshida K.Nasirova
nkhursh77@gmail.com
Toshkent davlat tibbiyot universiteti
Rano B.Alieva
ranoalieva@mail.ru
Respublika ixtisoslaştirilgan kardiologiya ilmiy-amaliy tibbiyot markazi
Barkamol U.Jumaboeva
barkamola2001@gmail.com
Toshkent davlat tibbiyot universiteti

Litsenziya

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Qanday iqtibos keltirish kerak

Dasturiy gemodializdagi 2-tip qandli diabetli bemorlarda glikemik nazoratning miokardial stressni bașorat qilișdagi ahamiyati (L. Daminova, S. Muminova, X. Nasirova, R. Alieva, & B. Jumaboeva, Trans.). (2026). O’ZBEKISTON KARDIOLOGIYASI, 3(3), 22-30. https://doi.org/10.70626/cardiouz-2026-3-00095
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