Prevalence of atherosclerotic lesions of the brachiocephalicarteries and their association with cardiovascular risk factors: a cross-sectional study in uzbekistan
Abstract
Aim. To assess the prevalence of atherosclerotic lesions of the brachiocephalic arteries (BCA), their association with cardiovascular risk factors, and cardiovascular risk according to the SCORE scale in the population of Uzbekistan.
Materials and methods. A cross-sectional study (conducted in 2025 using 2022 data) included 6,425 patients (47.6% men, 52.4% women; mean age 54.0 ± 23.1 years) at the Republican Specialized Scientific and Practical Medical Center of Cardiology, Uzbekistan. Carotid and brachiocephalic ultrasound was performed using a short protocol assessing stenosis in four segments [1]. The following parameters were analyzed: age, total cholesterol (TC), arterial hypertension (AH), smoking, systolic and diastolic blood pressure (SBP, DBP). Cardiovascular risk was determined using the SCORE system [2]. Statistical analysis was performed using SPSS 26.
Results. BCA lesions were detected in 54.8% of patients. Age correlated with the presence of lesions (Spearman’s ρ = 0.219, p < 0.01), while TC did not (ρ = 0.032, p = 0.207). Men over 50 years had more extensive lesions (7.9% with four affected segments) compared to women (2.6%). According to the SCORE scale, men and patients over 50 years had a moderate to high cardiovascular risk (4–8%).
Conclusion. Age is the key risk factor for atherosclerosis of the brachiocephalic arteries. The high prevalence of arterial hypertension emphasizes the need for preventive measures in Uzbekistan.
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List of references
Touboul PJ, Hennerici MG, Meairs S, et al. Mannheim intima-media thickness consensus. Cerebrovasc Dis. 2004;18(4):346-349. https://doi.org/10.1159/000081812.
Conroy RM, Pyo¨ra¨la¨ K, Fitzgerald AP, et al. Estimation of ten-year risk of fatal cardiovascular disease in Europe: the SCORE project. Eur Heart J. 2003;24(11):987-1003. https://doi.org/0.1016/s0195-668x(03)0 0114-3.
Polak JF, Szklo M, Kronmal RA, et al. The value of carotid artery plaque and intima-media thickness for incident cardiovascular disease: the multi-ethnic study of atherosclerosis. J Am Heart Assoc. 2013;2(2):e000087. Published 2013 Apr 8. https://doi.org/10.1161/JAHA.113.000087.
Lorenz MW, Markus HS, Bots ML, Rosvall M, Sitzer M. Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis. Circulation. 2007;115(4):459-467. https://doi.org/10.1161/CIRCULATIONAHA.106.628875.
World Health Organization. Global Health Observatory. Geneva, Switzerland: World Health Organization; 2020. Accessed October 12, 2025. https://www.who.int/data/gho/gho.
GBD 2013 Risk Factors Collaborators, Forouzanfar MH, Alexander L, et al. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2015;386(10010):2287-2323. https://doi.org/10.1016/S0140-6736(15)00128-2.
Yusuf S, Joseph P, Rangarajan S, et al. Modifiable risk factors, cardiovascular disease, and mortality in 155722 individuals from 21 high-income, middle-income, and low-income countries (PURE): a prospective cohort study. Lancet. 2020;395(10226):795-808. https://doi.org/10.1016/S0140-6736(19)32008-2.
McEvoy JW, McCarthy CP, Bruno RM, et al. 2024 ESC Guidelines for the management of elevated blood pressure and hypertension. Eur Heart J. 2024;45(38):3912-4018. https://doi.org/10.1093/eurheartj/ehae1 78.
Field A. Discovering Statistics Using IBM SPSS Statistics. 4th ed. Los Angeles, CA: SAGE Publications; 2013
GBD 2019 Risk Factors Collaborators. Global burden of 87 risk factors in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet. 2020;396(10258):1223-1249. https://doi.org/10.1016/S0140-6736(20)30752-2.
Teslovich TM, Musunuru K, Smith AV, et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature. 2010;466(7307):707–713. https://doi.org/10.1038/nature09270.
Copyright (c) 2025 Ф.М. Бекметова , М.Н. Хотамова , С.Я. Абдуллаева , Ш.А. Оринбаев (Автор)
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